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CAS No 50-33-9 , 4-butyl-1,2-diphenylpyrazolidine-3,5-dione

  • Name: 4-butyl-1,2-diphenylpyrazolidine-3,5-dione
  • Synonyms: Azolid; Butapirazol;4-butyl-1,2-diphenylpyrazolidine-3,5-dione;Butazolidin; Diphenylbutazone; Butacote; Butapyrazole; Fenilbutazona; Intrabutazone; Butadion;
  • CAS Registry Number:
  • Melting Point: 104-107 ºC
  • Flash Point: 174.3°C
  • Boiling Point: 424.9°Cat760mmHg
  • Density: 1.173g/cm3
  • Water Solubility: <0.1 G/100 ML AT 23.5 ºC
  • Safety Statements: R45;R20/21/22;R36/37/38;R42/43
  • Hazard Symbols: Xn: Harmful;T: Toxic;
  • Flash Point: 174.3°C
  • EINECS: 200-029-0
  • Molecular Weight: 308.3743
  • InchiKey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)
    16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
  • Risk Statements: S53;S22;S26;S36/37/39;S45
  • Molecular Formula: C19H20N2O2
  • Molecular Structure:CAS No:50-33-9 4-butyl-1,2-diphenylpyrazolidine-3,5-dione
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50-33-9 PHENYLBUTAZONE; 99%

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
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50-33-9 Phenylbutazone

  • Name:Phenylbutazone EINECS:200-029-0 Molecular Formula:C19H20N2O2 CAS :50-33-9; Synonyms:4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione; 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one InChI:InChI=1/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 Appearance:off-...
  • China Hubei Yuancheng Saichuang Technology Ltd.,.Co [Manufacturer]
  • Tel: 86-027-50756085
  • Fax: --
  • Address: No.496,Zhongshan Road,Wuchang District, Wuhan Wuhan,HubeiChina
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50-33-9 Phenylbutazone

  • Product name:Phenylbutazone Synonyms4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione;1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazoline Molecular Formula:C19H20N2O2 CAS number:50-33-9 Molecular Weight:308.38 Characteristics:White or almost white crystalline powder...
  • China Zhongbei Northland Bio-Chem Industry Co., Ltd [Manufacturer]
  • Tel: 86-452-6197119
  • Fax: 86-452-6197939
  • Address: 5F, C Liandalijing Bulding,No 259 Xinjiang Road, Jianhua District Qiqihar,HeilongjiangChina
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50-33-9 Phenylbutazone

  • IUPAC NAME-4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione MOLECULAR FORMULA-C19H20N2O2 MOLAR MASS-308.374 g/mol In the United States and United Kingdom, it is no longer approved for human use,
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641875
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

50-33-9 Phenylbutazone

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50-33-9 Phenylbutazone

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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50-33-9 PHENYLBUTAZONE

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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50-33-9 Phenylbutazone

  • Phenylbutazone No.4 Formula:C19H20N2O2 Molecular weight:308.4 CAS No.:50-33-9 Quality Standards:Ph. Eur.4/USP29,Ph. Eur,WSB1996 Characteristics:A white or almost white, crystalline powder, practically insoluble in water, soluble in ether, sparingly s...
  • China Zhongbei No thland Bio-Chem Indust y Co., Ltd. [Manufacturer]
  • Tel: 86-452-6055586
  • Fax: 86-452-6197939
  • Address: 5F, C Liandalijing Bulding,No 259 Xinjiang Road, Jianhua District, Qiqiha'er City, Heilongjiang Province, China Qiqihaer,HeilongjiangChina

50-33-9 Phenylbutazone

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
  • Fax: +86-571-85420103
  • Address: 607, North Zhongshan Road, Hangzhou 310000 China ,ZhejiangChina
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50-33-9 Phenylbutazone

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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References of 4-butyl-1,2-diphenylpyrazolidine-3,5-dione
Title: Phenylbutazone
CAS Registry Number: 50-33-9
CAS Name: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
Synonyms: 4-butyl-1,2-diphenyl-3,5-dioxopyrazolidine; 3,5-dioxo-1,2-diphenyl-4-n-butylpyrazolidine; flexazone; diphebuzol; fenibutazona
Manufacturers' Codes: G-13871; R-3-ZON
Trademarks: Ambene (Merckle); Artrizin (Leo Pharm); Azolid (USV); Bizolin (Boehringer, Ing.); Butacote (Novartis); Butadion (Streuli); Butapirazol (Polfa); Butadiona (Miquel-Otsuka); Butatron (Sanofi); Butoz (Hamilton); Butazolidin (Novartis); Buzon (Knoll); Ecobutazone (Empire); Equipalazone (NCN); Exrheudon N (Optimed); Fenibutol (Atral); Intrabutazone (Organon); Intrazone (Arnolds); Mepha-Butazon (Mepha); Phenyzene (C-Vet); Robizone-V (Robins); Tevcodyne (Tevcon); Uzone (Douglas)
Molecular Formula: C19H20N2O2
Molecular Weight: 308.37
Percent Composition: C 74.00%, H 6.54%, N 9.08%, O 10.38%
Literature References: Prepn: Stenzl, US 2562830 (1951 to Geigy); cf. GB 812449 (1959 to Geigy). Review of synthesis: Ullmanns Encyklop?die der technischen Chemie vol. 13, 298 (1962). Physical properties and pharmacology: v. Rechenberg, Phenylbutazone (Edward Arnold, London, 1962) 197 pp. Acute toxicity: T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986). Soly data: Pulver et al., Schweiz. Med. Wochenschr. 86, 1080 (1956). Comprehensive description: S. L. Ali, Anal. Profiles Drug Subs. 11, 483-521 (1982). Review of hematological effects: G. A. Faich, Pharmacotherapy 7, 25 (1987).
Properties: Crystals from ethanol, mp 105°. Soly in water at 22.5°: 0.7 mg/ml (also reported as 2.2 mg/ml). pK 4.5 (from uv in water), pK 4.89 (titration in 50% ethanol), pK 5.25 (titration in 80% 2-methoxyethanol). uv max (acid methanol): 239.5 nm (log e 4.19).
Melting point: mp 105°
pKa: pK 4.5 (from uv in water), pK 4.89 (titration in 50% ethanol), pK 5.25 (titration in 80% 2-methoxyethanol)
Absorption maximum: uv max (acid methanol): 239.5 nm (log e 4.19)
 
Derivative Type: Sodium salt
CAS Registry Number: 129-18-0
Manufacturers' Codes: GP-26872
Trademarks: Elmedal (Thiemann)
Molecular Formula: C19H19N2NaO2
Molecular Weight: 330.36
Percent Composition: C 69.08%, H 5.80%, N 8.48%, Na 6.96%, O 9.69%
Properties: Crystals, freely sol in water. pH of aq solns ~8.2.
 
Derivative Type: Calcium salt
Trademarks: Ticinil Calcico (De Angeli)
Molecular Formula: C38H36CaN4O4
Molecular Weight: 652.79
Percent Composition: C 69.92%, H 5.56%, Ca 6.14%, N 8.58%, O 9.80%
Properties: LD50 in adult male, female rats (mg/kg): 1311, 647 orally (Gaines, Linder).
Toxicity data: LD50 in adult male, female rats (mg/kg): 1311, 647 orally (Gaines, Linder)
 
Derivative Type: Piperazine salt
Synonyms: Pyrazinobutazone; pyrasanone
Trademarks: Carudol (Fher)
Molecular Formula: C19H20N2O2.C4H10N2
Molecular Weight: 394.51
Percent Composition: C 70.02%, H 7.66%, N 14.20%, O 8.11%
Properties: mp 140-141° (solidifies and remelts at ~180°).
Melting point: mp 140-141° (solidifies and remelts at ~180°)
 
Derivative Type: 2-Amino-2-thiazoline salt
CAS Registry Number: 54749-86-9
CAS Name: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione compd with 4,5-dihydro-2-thiazolamine (1:1)
Synonyms: thiazolinobutazone; TZB
Manufacturers' Codes: LAS-11871
Trademarks: Fordonal (Almirall)
Molecular Formula: C22H26N4O2S
Molecular Weight: 410.53
Percent Composition: C 64.36%, H 6.38%, N 13.65%, O 7.79%, S 7.81%
Literature References: Prepn: J. Moragues et al., Arzneim.-Forsch. 24, 1785 (1974). Pharmacology: M. Márquez, D. J. Roberts, ibid. 1786, 1790; M. Colombo et al., ibid. 26, 1347 (1976).
Properties: White crystals, mp 164-166°. LD50 orally in rats, mice: 1425, 1650 mg/kg (Colombo).
Melting point: mp 164-166°
Toxicity data: LD50 orally in rats, mice: 1425, 1650 mg/kg (Colombo)
 
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Analgesic; anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Pyrazolones.