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CAS No 488-41-5 , D-Mannitol,1,6-dibromo-1,6-dideoxy-

  • Name: D-Mannitol,1,6-dibromo-1,6-dideoxy-
  • Synonyms: Mielobromol; Dibromannit; Dibromomannitol; DBM; NSC 94110; Myebrol; 1,6-Dibromo-1,6-dideoxy-D-mannitol; D-Dibromomannitol; 1,6-Dibromo-D-mannitol;Mannitol,1,6-dibromo-1,6-dideoxy-, D- (8CI); 1,6-Dibromomannitol; NCI C04762; NSC 94100;Dibromannitol; R 54;Myelobromol;1,6-Dideoxy-1,6-dibromo-D-mannitol;1,6-Dibromo-1,6-dideoxymannitol; Mitobronitol;D-Mannitol,1,6-dibromo-1,6-dideoxy-;
  • CAS Registry Number:
  • Flash Point: 263°C
  • Boiling Point: 511.2°Cat760mmHg
  • Density: 2.117g/cm3
  • Refractive index: 1.622
  • Safety Statements: Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Br−.
  • Hazard Symbols: T: Toxic;
  • Flash Point: 263°C
  • EINECS: 207-676-8
  • Molecular Weight: 308.00
  • InChI: InChI=1/C6H12Br2O4/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,9-12H,1-2H2/t3-,4-,5+,6+/m0/s1
  • Risk Statements: 45-22
  • Molecular Formula: C6H12 Br2 O4
  • Molecular Structure:CAS No:488-41-5 D-Mannitol,1,6-dibromo-1,6-dideoxy-

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References of D-Mannitol,1,6-dibromo-1,6-dideoxy-
Title: Mitobronitol
CAS Registry Number: 488-41-5
CAS Name: 1,6-Dibromo-1,6-dideoxy-D-mannitol
Synonyms: 1,6-dideoxy-1,6-dibromo-D-mannitol; dibromomannitol; DBM
Trademarks: Myebrol (Kyorin); Myelobromol (Enzypharm)
Molecular Formula: C6H12Br2O4
Molecular Weight: 307.97
Percent Composition: C 23.40%, H 3.93%, Br 51.89%, O 20.78%
Literature References: Cytostatic agent; the first dibromohexitol introduced into clinical use. Manuf: GB 959407 (1964 to Chinoin). Pharmaco-biochemical studies: J. Szabo et al., Neoplasma 20, 13 (1973). Clinical studies: D. F. Chiuten et al., Cancer 47, 442 (1981). Comparative study with busulfan, q.v.: R. T. Silver et al., Cancer 60, 1442 (1987).
Properties: Crystals from methanol + dichloroethane, mp 176-178°.
Melting point: mp 176-178°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents.