Home > Name List By i > Isotretinoin

CAS No 4759-48-2 , Isotretinoin

  • Name: Isotretinoin
  • Synonyms: 13-cis-Retinoic acid; 13-cis-vitamin a acid; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid;Isotretinoin;13-cis-retinoic acid; 13-cis-Vitamin A acid;
  • CAS Registry Number:
  • Melting Point: 174-177 ºC
  • Density: 1.011 g/cm3
  • Safety Statements: R36/37/38;R61
  • Hazard Symbols: T: Toxic;
  • EINECS: 225-296-0
  • Molecular Weight: 300.44
  • InChI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
  • Risk Statements: S26;S37/39;S45;S53
  • Molecular Formula: C20H28O2
  • Molecular Structure:CAS No:4759-48-2 Isotretinoin

Related products

Search by region :

Select to

4759-48-2 isotretinoin

  • China YANGZHOU CHEMICAL CO.,LTD. [Manufacturers]
  • Tel: 86-514-87864167
  • Fax: +86-514-87859301,87859302,87859303
  • Address: 7/F,18 WEST WENCHANG ROAD,YANGZHOU,JIANGSU,CHINA yangzhou,jiangsuChina
Contact Supplier

4759-48-2 13-cis-Retinoic Acid

Contact Supplier

4759-48-2 13-cis-Retinoic Acid

  • Hong kong Leawell International Limited [Importer/Exporter]
  • Tel: +852-(2576)-0298
  • Fax: +852-(2895)-4635
  • Address: 18/F Catic Plaza, 8 Causeway Road Causeway Bay, Guangzhou,GuangdongHong kong
Contact Supplier

4759-48-2 Isotretinoin

  • China Saniver Limited null
  • Fax: +86-21-62882088 +86-852-23333065
  • Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong. null,nullChina
Contact Supplier

4759-48-2 ISOTRETINOIN

  • China IFFECT CHEMPHAR CO., LTD. null
  • Tel: 0086 755-83761619 83760606
  • Fax: +86-25- 84270111
  • Address: 15A,Changfa Center, Building B ,No. 300,East Zhongshan Road,Baixia District,Nanjing,210002, P.R.China. Nanjing,JiangshuChina
Contact Supplier

4759-48-2 Isotretinoin

  • China EASYBUYER LTD., [Manufacturers]
  • Tel: +86-21-35015877 +86-13701868511
  • Fax: +86-21-35010877
  • Address: Room 407, Building 10, Hi-Shanghai Center, No.990 Dalian Rd,Shanghai 200092 China null,ShanghaiChina
Contact Supplier

4759-48-2 Isotretinoin

  • China Hwasun Biotechnology Co., Ltd. null
  • Fax: 86-21-64765024
  • Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China null,nullChina
Contact Supplier

4759-48-2 isotretinoin

Contact Supplier

4759-48-2 Isotretinoin

Contact Supplier

4759-48-2 Isotretinoin

  • China YUANFU INDUSTRY CO., LTD. null
  • Fax: +86-551-2818319
  • Address: Building 19, Huposhanzhuang , Changjiang Road , Hefei,China null,nullChina
Contact Supplier

Select to

10/17
Previous 6 7 8 9 10 11 12 13 14 15 Next
References of Isotretinoin
Title: Isotretinoin
CAS Registry Number: 4759-48-2
CAS Name: 13-cis-Retinoic acid
Synonyms: 2-cis-vitamin A acid; neovitamin A acid
Manufacturers' Codes: Ro-4-3780
Trademarks: Accutane (Roche); Isotrex (Stiefel); Oratane (Douglas); Roaccutane (Roche)
Molecular Formula: C20H28O2
Molecular Weight: 300.44
Percent Composition: C 79.95%, H 9.39%, O 10.65%
Literature References: Naturally occurring metabolite of vitamin A, q.v.; inhibits sebum production. Prepn: C. D. Robeson et al., J. Am. Chem. Soc. 77, 4111 (1955). Stereoselective process: R. Lucci, EP 111325; idem, US 4556518 (1984, 1985 both to Hoffmann-La Roche). Toxicology and teratogenicity study: J. J. Kamm, J. Am. Acad. Dermatol. 6, 652 (1982). Identification as endogenous metabolite of all-trans-retinoic acid: M. E. Cullum, M. H. Zile, J. Biol. Chem. 260, 10590 (1985). HPLC determn in serum: G. Tang, R. M. Russell, J. Lipid Res. 31, 175 (1990). Review of pharmacology and clinical efficacy in acne: A. R. Shalita et al., Cutis 42, Suppl. 6A, 1-19 (1988). Symposium on clinical experience: Dermatology 195, Suppl. 1, 1-37 (1997).
Properties: Reddish-orange plates from isopropyl alcohol, mp 174-175°. uv max: 354 nm (e 39800). LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm).
Melting point: mp 174-175°
Absorption maximum: uv max: 354 nm (e 39800)
Toxicity data: LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)
Therap-Cat: Antiacne.
Keywords: Antiacne.