Home > Name List By other > (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de, g]quinoline

CAS No 475-81-0 , (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,
g]quinoline

  • Name: (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,
    g]quinoline
  • Synonyms: (+)-Glaucine;(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,
    g]quinoline; 475-81-0; Boldine dimethyl ether; d-Glaucine; S-(+)-Glaucine;Bromcholitin; NSC34396; Glauvent;
  • CAS Registry Number:
  • Flash Point: 140.2°C
  • Boiling Point: 487°Cat760mmHg
  • Density: 1.166g/cm3
  • Refractive index: 1.575
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 140.2°C
  • EINECS: 207-501-5
  • Molecular Weight: 355.4275
  • InchiKey: RUZIUYOSRDWYQF-HNNXBMFYSA-N
  • InChI: InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16
    (23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
  • Molecular Formula: C21H25NO4
  • Molecular Structure:CAS No:475-81-0 (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,<br />g]quinoline

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References of (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,
g]quinoline
Title: Glaucine
CAS Registry Number: 475-81-0
CAS Name: (6aS)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
Synonyms: 1,2,9,10-tetramethoxyaporphine; boldine dimethyl ether
Trademarks: Bromcholitin; Glauvent
Molecular Formula: C21H25NO4
Molecular Weight: 355.43
Percent Composition: C 70.96%, H 7.09%, N 3.94%, O 18.01%
Literature References: d-Form prevalent in nature. Found in Glaucium flavum Crantz (G. luteum Scop.), Papaveraceae and in Dicentra and Corydalis species, Fumariaceae. Isoln: Fischer, Arch. Pharm. 239, 426 (1901). Structure and prepn: Gadamer, ibid. 249, 680 (1911); Sp?th, Tharrer, Ber. 66, 904 (1933). Configuration: Faltis, Adler, Arch. Pharm. 284, 281 (1951). Synthesis of dl-form: Chan, Maitland, J. Chem. Soc. C 1966, 753; Jackson, Martin, ibid. 2061; Cava et al., J. Org. Chem. 35, 175 (1970). Pharmacology and toxicity of dl-glaucine phosphate: Y. Kasé et al., Arzneim.-Forsch. 33, 936 (1983). Sites of antitussive action: eidem, ibid. 947.
Properties: Orthorhombic plates, prisms from ethyl acetate or ether, mp 120°. [a]D20 +115° (c = 3 in alc). Sol in acetone, alcohol, chloroform, ethyl acetate. Moderately sol in ether, petr ether. Practically insol in water and benzene.
Melting point: mp 120°
Optical Rotation: [a]D20 +115° (c = 3 in alc)
 
Derivative Type: Hydrochloride trihydrate
Molecular Formula: C21H25NO4.HCl.3H2O
Molecular Weight: 445.93
Percent Composition: C 56.56%, H 7.23%, N 3.14%, O 25.12%, Cl 7.95%
Properties: Needles. mp 232° (anhydrous). Sol in water, alcohol, chloroform.
Melting point: mp 232° (anhydrous)
 
Derivative Type: Hydrobromide
Molecular Formula: C21H25NO4.HBr
Molecular Weight: 436.34
Percent Composition: C 57.80%, H 6.01%, N 3.21%, O 14.67%, Br 18.31%
Properties: Crystals, mp 235°. Less sol than the hydrochloride.
Melting point: mp 235°
 
Derivative Type: dl-Form phosphate
Manufacturers' Codes: DL-832
Molecular Formula: (C21H25NO4)2.3H3PO4
Molecular Weight: 1004.84
Percent Composition: C 50.20%, H 5.92%, N 2.79%, O 31.84%, P 9.25%
Properties: Crystalline powder. LD50 in mice (mg/kg): 98 i.v.; 401 orally (Kasé).
Toxicity data: LD50 in mice (mg/kg): 98 i.v.; 401 orally (Kasé)