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CAS No 454-14-8 , Cuscohygrine

  • Name: Cuscohygrine
  • Synonyms: 1,3-Bis[(2S)-1-methylpyrrolidin-2-yl]propan-2-one;Cuscohygrine;
  • CAS Registry Number:
  • Density: 0.989 g/cm3
  • Refractive index: 1.488
  • Molecular Weight: 224.34
  • InChI: InChI=1/C13H24N2O/c1-14-7-3-5-11(14)9-13(16)10-12-6-4-8-15(12)2/h11-12H,3-10H2,1-2H3
  • Molecular Formula: C13H24N2O
  • Molecular Structure:CAS No:454-14-8 Cuscohygrine

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454-14-8 Cuscohygrine

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454-14-8 2-Propanone,1-[(2R)-1-methyl-2-pyrrolidinyl]-3-[(2S)-1-methyl-2-pyrrolidinyl]-, rel-

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References of Cuscohygrine
Title: Cuscohygrine
CAS Registry Number: 454-14-8
CAS Name: 1,3-Bis(1-methyl-2-pyrrolidinyl)-2-propanone
Synonyms: cuskhygrine; bellaradine
Molecular Formula: C13H24N2O
Molecular Weight: 224.34
Percent Composition: C 69.60%, H 10.78%, N 12.49%, O 7.13%
Literature References: In coca leaves of various origin. Found in crude hygrine. Readily converted to hygrine by acids and bases. Isoln: Liebermann, Ber. 22, 679 (1898); Liebermann, Cybulski, ibid. 28, 578 (1895). Identity with bellaradine: Steinegger, Phokas, Pharm. Acta Helv. 30, 441 (1955). Structure: Hess, Fink, Ber. 53, 794 (1920); Sohl, Shriner, J. Am. Chem. Soc. 55, 3828 (1933); Rapoport, Jorgensen, J. Org. Chem. 14, 664 (1949). Synthesis: Sp?th, Tuppy, Monatsh. Chem. 79, 119 (1948); Galinovsky et al., ibid. 82, 551 (1951). Enzymatic synthesis: Tuppy, Faltaous, ibid. 91, 167 (1960). Stereochemistry: Galinovsky, Zuber, ibid. 84, 798 (1953). Biosynthesis: E. Leete, Chem. Commun. 1980, 1170.
Properties: Oily liquid, bp23 169-170°; bp14 152°; bp2 118-125°. d420 0.9733. nD20 1.4832. Miscible with water. Sol in alcohol, ether, benzene.
Boiling point: bp23 169-170°; bp14 152°; bp2 118-125°
Index of refraction: nD20 1.4832
Density: d420 0.9733
 
Derivative Type: Hemiheptahydrate
Properties: Needles, mp 40°.
Melting point: mp 40°
 
Derivative Type: Hydrobromide
Molecular Formula: C13H24N2O.2HBr
Molecular Weight: 386.17
Percent Composition: C 40.43%, H 6.79%, N 7.25%, O 4.14%, Br 41.38%
Properties: Prisms from alc, mp 234°.
Melting point: mp 234°