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CAS No 446-86-6 , 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine

  • Name: 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
  • Synonyms: 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine; Azathioprin; Imurel; Azatioprin; Azothioprine; Imurek; Ccucol;Imuran; Azamun; Azanin;
  • CAS Registry Number:
  • Melting Point: 243-244 ºC
  • Density: 1.9 g/cm3
  • Refractive index: 1.923
  • Water Solubility: <0.1 G/100 ML AT 23 ºC
  • Safety Statements: S53;S22;S26;S36/37;S45;S36;
  • Hazard Symbols: Xi,T,Xn
  • EINECS: 207-175-4
  • Molecular Weight: 277.26258
  • InchiKey: LMEKQMALGUDUQG-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-
    13-8/h2-4H,1H3,(H,10,11,12,13)
  • Risk Statements: 45-22-36/37/38-20/21/22
  • Molecular Formula: C9H7N7O2S
  • Molecular Structure:CAS No:446-86-6 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine

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References of 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
Title: Azathioprine
CAS Registry Number: 446-86-6
CAS Name: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine
Synonyms: 6-(1-methyl-4-nitro-5-imidazolyl)mercaptopurine; azothioprine
Manufacturers' Codes: BW-57-322; NSC-39084
Trademarks: Azanin (Tanabe); Imuran (GSK); Imurek (GSK); Imurel (GSK); Zytrim (Isis Puren)
Molecular Formula: C9H7N7O2S
Molecular Weight: 277.26
Percent Composition: C 38.99%, H 2.54%, N 35.36%, O 11.54%, S 11.56%
Literature References: Immunosuppressive antimetabolite; also active as disease modifying antirheumatic drug (DMARD). Metabolized in vivo to 6-mercaptopurine, q.v. Prepn: G. H. Hitchings, G. B. Elion, US 3056785 (1962 to Burroughs Wellcome). Metabolism and pharmacokinetics: T. L. Ding, L. Z. Benet, Drug Metab. Dispos. 7, 373 (1979). Carcinogenicity studies: P. S. Mitrou et al., Arzneim.-Forsch. 29, 483, 662 (1979). HPLC determn in plasma: E. C. Van Os et al., J. Chromatogr. B 679, 147 (1996). Clinical trial in rheumatoid arthritis: R. F. Wilkens, D. Stablein, J. Rheumatol. 23, Suppl. 44, 64 (1996). Comprehensive description: W. P. Wilson, S. A. Benezra, Anal. Profiles Drug Subs. 10, 29-53 (1981). Review of clinical efficacy in renal transplantation: G. L. C. Chan et al., Pharmacotherapy 7, 165-177 (1987); in multiple sclerosis: C. Confavreux, T. Moreau, Mult. Scler. 1, 379-384 (1996); in inflammatory bowel disease: W. J. Sandborn, Scand. J. Gastroenterol. 33, Suppl. 225, 92-99 (1998).
Properties: Pale yellow crystals from 50% aq acetone, dec 243-244°. uv max (methanol): 276 nm (e 1.82 ′ 104); (0.1N HCl): 280 nm (e 1.73 ′ 104); (0.1N NaOH): 285 nm (e 1.55 ′ 104). pKa2 8.2. Slightly sol in chloroform, ethanol. Practically insol in water.
pKa: pKa2 8.2
Absorption maximum: uv max (methanol): 276 nm (e 1.82 ′ 104); (0.1N HCl): 280 nm (e 1.73 ′ 104); (0.1N NaOH): 285 nm (e 1.55 ′ 104)
 
Derivative Type: Sodium salt
CAS Registry Number: 55774-33-9
Molecular Formula: C9H6N7NaO2S
Molecular Weight: 299.24
Percent Composition: C 36.12%, H 2.02%, N 32.77%, Na 7.68%, O 10.69%, S 10.72%
Properties: Soly in water: 10 mg/ml.
 
CAUTION: Azathioprine is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-25.
Therap-Cat: Immunosuppressant; antirheumatic.
Keywords: Antiarthritic/Antirheumatic; Immunosuppressant.