Title: Ethacridine
CAS Registry Number: 442-16-0
CAS Name: 7-Ethoxy-3,9-acridinediamine
Synonyms: 6,9-diamino-2-ethoxyacridine; 2,5-diamino-7-ethoxyacridine; 2-ethoxy-6,9-diaminoacridine; etakridin
Molecular Formula: C15H15N3O
Molecular Weight: 253.30
Percent Composition: C 71.13%, H 5.97%, N 16.59%, O 6.32%
Literature References: Prepn:
DE 364033;
DE 364037;
DE 393411;
DE 395683 (1922);
Frdl. 14, 804, 807-812; A. Albert, W. Gledhill,
J. Soc. Chem. Ind. 61, 159 (1942). Toxicity: S. D. Rubbo,
Br. J. Exp. Pathol. 28, 1 (1947); N. J. Joshi
et al., Indian J. Exp. Biol. 16, 1038 (1978). Pharmacokinetics: T. J. Rising
et al., Arzneim.-Forsch. 27, 872 (1977). Use in protein analysis: R. H. Yue
et al., Thromb. Diath. Haemorrh. 31, 439 (1974); F. Franek,
Methods Enzymol. 121, 631-638 (1986); in serological detection of
Brucella sp.: J. D. Huber, P. Nicoletti,
Am. J. Vet. Res. 47, 1529 (1986). Clinical evaluation in diarrhea: N. Madanagopalan
et al., Curr. Ther. Res. 18, 546 (1975); R. Raedsch
et al., Klin. Wochenschr. 69, 863 (1991); as an abortifacient: S. Gardo, M. Nagy,
Arch. Gynecol. Obstet. 247, 39 (1990).
Properties: Orange-yellow crystals from 50% alc. mp 226°.
Melting point: mp 226°
Derivative Type: Lactate monohydrate
CAS Registry Number: 6402-23-9
Synonyms: Acrinol
Trademarks: Rimaon; Rivanol (Winthrop); Vucine; Acrolactine; Ethodin (Winthrop); Metifex (Cassella-med)
Molecular Formula: C15H15N3O.C3H6O3.H2O
Molecular Weight: 361.39
Percent Composition: C 59.82%, H 6.41%, N 11.63%, O 22.14%
Properties: Light yellow crystals from 90% alcohol + ether. Darkens at 200°, mp 235°. Slowly sol in 15 parts water; sol in 9 parts boiling water; in 110 parts alcohol at 22°, in 100 parts boiling alcohol. Solns are yellow, fluorescent and stable to boiling. LD50 s.c. in mice: 0.12 g/kg (Rubbo).
Melting point: mp 235°
Toxicity data: LD50 s.c. in mice: 0.12 g/kg (Rubbo)
Use: Reagent in serological testing and protein chemistry.
Therap-Cat: Antiseptic. Abortifacient.
Keywords: Antiseptic/Disinfectant; Dyes.
