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CAS No 42971-09-5 , Vinpocetine

  • Name: Vinpocetine
  • Synonyms: Ethyl apovincamin-22-oate; Ethyl (+)-apovincaminate;Vinpocetine;Cavinton; Apovincaminic acid ethyl ester; 42971-09-5; TCV-3B;
  • CAS Registry Number:
  • Density: 1.28 g/cm3
  • Water Solubility: DMSO: 5 mg/mL
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 256-028-0
  • Molecular Weight: 350.45404
  • InchiKey: DDNCQMVWWZOMLN-IRLDBZIGSA-N
  • InChI: InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19
    (16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,
    1-2H3/t20-,22+/m1/s1
  • Risk Statements: S36
  • Molecular Formula: C22H26N2O2
  • Molecular Structure:CAS No:42971-09-5 Vinpocetine

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References of Vinpocetine
Title: Vinpocetine
CAS Registry Number: 42971-09-5
CAS Name: (3a,16a)-Eburnamenine-14-carboxylic acid ethyl ester
Synonyms: 3a,16a-apovincaminic acid ethyl ester; ethyl apovincamin-22-oate
Manufacturers' Codes: RGH-4405
Trademarks: Cavinton (Thiemann)
Molecular Formula: C22H26N2O2
Molecular Weight: 350.45
Percent Composition: C 75.40%, H 7.48%, N 7.99%, O 9.13%
Literature References: Deriv of vincamine, q.v., with vasodilating activity. Prepn: C. L?rincz et al., DE 2253750; eidem, US 4035370 (1973, 1977 both to Gedeon Richter); eidem, Arzneim.-Forsch. 26, 1907 (1976). Series of articles on pharmacology, biochemistry, metabolism, pharmacokinetics, clinical studies: ibid. 1908-1989. Toxicity studies: E. Pálosi, L. Szporny, ibid. 1926; E. Cholnoky, L. I. D?m?k, ibid. 1939. HPLC studies: G. Szepesi, M. Gazdag, J. Chromatogr. 205, 57, 341 (1981). Evaluation of effectiveness as antimotion drug: E. I. Matsnev, D. Bodo, Aviat. Space Environ. Med. 55, 281 (1984). One-pot synthesis from vincamine: Y. Kuge et al., Synth. Commun. 24, 759 (1994).
Properties: Crystals from benzene, mp 147-153° (dec). [a]D20 +114° (c = 1 in pyridine). uv max (96% ethanol): 229, 275, 315 nm (log e 4.45, 4.08, 3.85). LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, D?m?k).
Melting point: mp 147-153° (dec)
Optical Rotation: [a]D20 +114° (c = 1 in pyridine)
Absorption maximum: uv max (96% ethanol): 229, 275, 315 nm (log e 4.45, 4.08, 3.85)
Toxicity data: LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, D?m?k)
Therap-Cat: Vasodilator (cerebral).
Keywords: Vasodilator (Cerebral).