Home > Name List By 3 > 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1- nitrosourea China

CAS No 42471-28-3 , 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-
nitrosourea Search by region : China

  • Name: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-
    nitrosourea
  • Synonyms: Nimustina; Nimustinum [INN-Latin];3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-
    nitrosourea; 42471-28-3; Nimustinum; CCRIS 2751; Nimustina [INN-Spanish];Nimustin; Nimustine [INN];
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.52g/cm3
  • Safety Statements: Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 255-838-1
  • Molecular Weight: 272.69152
  • InchiKey: VFEDRRNHLBGPNN-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H13ClN6O2/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10/
    h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14)
  • Risk Statements: 25
  • Molecular Formula: C9H13ClN6O2
  • Molecular Structure:CAS No:42471-28-3 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-<br />nitrosourea

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References of 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-
nitrosourea
Title: Nimustine
CAS Registry Number: 42471-28-3
CAS Name: N￠-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
Molecular Formula: C9H13ClN6O2
Molecular Weight: 272.69
Percent Composition: C 39.64%, H 4.81%, Cl 13.00%, N 30.82%, O 11.73%
Literature References: Chloroethylnitrosourea derivative with antitumor activity. Prepn: H. Nakao et al., DE 2257360; eidem, US 4003901 (1973, 1977 both to Sankyo); eidem, Yakugaku Zasshi 94, 1932 (1974), C.A. 82, 43263y (1975). Effects on macrophage cytostatic activity in rats: N. Saijo et al., Br. J. Cancer 42, 162 (1980). Distribution, excretion, metabolism in mice: M. Tanaka et al., Cancer Treat. Rep. 64, 575 (1980). Exptl and clinical effect: N. Saijo et al., Cancer Chemother. Pharmacol. 4, 165 (1980). Acute toxicity: H. Masuda et al., Sankyo Kenkyusho Nempo 29, 118 (1977), C.A. 88, 146298s (1978).
Properties: Pale yellow crystals from ethanol, dec 125°.
 
Derivative Type: Hydrochloride
CAS Registry Number: 55661-38-6
Manufacturers' Codes: NSC-245382
Trademarks: ACNU (Baxter); Nidran (Sankyo)
Molecular Formula: C9H13ClN6O2.HCl
Molecular Weight: 309.15
Percent Composition: C 34.97%, H 4.56%, Cl 22.94%, N 27.18%, O 10.35%
Properties: White to light yellow cryst powder. uv max (0.04N HCl): 245 nm (E1%1cm 480-510). Sol in methanol, slightly sol in abs ethanol, n-butanol. Practically insol in ethyl acetate, ether, chloroform, benzene, n-hexane. Gradually develops greenish yellow color in light; decomposes slowly in humid air. LD50 in mice, rats (mg/kg): 62, 46 i.v. (Masuda).
Absorption maximum: uv max (0.04N HCl): 245 nm (E1%1cm 480-510)
Toxicity data: LD50 in mice, rats (mg/kg): 62, 46 i.v. (Masuda)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.