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CAS No 4214-72-6 , N-propan-2-ylpyrimidin-2-amine

  • Name: N-propan-2-ylpyrimidin-2-amine
  • Synonyms: Isaxoninum [INN-Latin];N-propan-2-ylpyrimidin-2-amine; 4214-72-6; N-(1-methylethyl)-; 2-Pyrimidinamine; Isaxoninum;2-(Isopropylamino)pyrimidine; Isaxonina;
  • CAS Registry Number:
  • Density: 1.065 g/cm3
  • Refractive index: 1.554
  • EINECS: 265-845-1
  • Molecular Weight: 137.18234
  • InchiKey: FTCYIGBVOHNHCD-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H11N3/c1-6(2)10-7-8-4-3-5-9-7/h3-6H,1-2H3,(H,8,9,10)
  • Molecular Formula: C7H11N3
  • Molecular Structure:CAS No:4214-72-6 N-propan-2-ylpyrimidin-2-amine

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4214-72-6 2-Pyrimidinamine, N-(1-methylethyl)- (9CI)

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4214-72-6 2-PYRIMIDINAMINE, N-(1-METHYLETHYL)- (9CI)

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4214-72-6 ISAXONINE

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References of N-propan-2-ylpyrimidin-2-amine
Title: Isaxonine
CAS Registry Number: 4214-72-6
CAS Name: N-(1-Methylethyl)-2-pyrimidinamine
Synonyms: 2-(isopropylamino)pyrimidine
Molecular Formula: C7H11N3
Molecular Weight: 137.18
Percent Composition: C 61.29%, H 8.08%, N 30.63%
Literature References: Neurotropic agent that promotes neurite outgrowth. Prepn: D. J. Brown, J. S. Harper, J. Chem. Soc. 1965, 5542. Prepn of pharmacologically active salts: A. Esanu, BE 788648; idem, US 3984414; idem, DE 2707095; idem, US 4073895 (1973, 1976, 1977, 1978 all to Soc. d'Etudes Prod. Chim.). Nerve growth promoting action: A. Hugelin et al., C.R. Seances Acad. Sci. Ser. D 285, 1339 (1977); eidem, Experientia 35, 626 (1979). Enhancement of muscle re-innervation in man: A. Sebille, A. Hugelin, Br. J. Pharmacol. 9, 275 (1980). Series of articles on in vitro effects, pharmacology, clinical studies: Nouv. Presse Med. 11, 1189-1280 (1982).
Properties: mp 27-28°. bp12 92-93°.
Melting point: mp 27-28°
Boiling point: bp12 92-93°
 
Derivative Type: Phosphate
CAS Registry Number: 65606-21-5
Trademarks: Nerfactor (Ipsen)
Molecular Formula: C7H11N3.H3PO4
Molecular Weight: 235.18
Percent Composition: C 35.75%, H 6.00%, N 17.87%, P 13.17%, O 27.21%
Properties: White crystalline powder, mp 125°. LD50 in mice (g/kg): 2.83 orally; 1.53 i.p. (Esanu, 1978).
Melting point: mp 125°
Toxicity data: LD50 in mice (g/kg): 2.83 orally; 1.53 i.p. (Esanu, 1978)
 
Therap-Cat: In treatment of peripheral neuropathies.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.