Home > Name List By 5 > 5-O-ethyl 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate China

CAS No 39562-70-4 , 5-O-ethyl 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Search by region : China

  • Name: 5-O-ethyl 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: Deiten; Bylotensin;Baypress;5-O-ethyl 3-O-methyl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Nidrel; Nitrendipino; Nitrendipin; Nitrendipinum; Bayotensin; Nitrepin;
  • CAS Registry Number:
  • Melting Point: 1580C
  • Boiling Point: 489
  • Density: 1.247 g/cm3
  • Refractive index: 1.579
  • Water Solubility: Insoluble
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 254-513-1
  • Molecular Weight: 360.3612
  • InchiKey: PVHUJELLJLJGLN-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)
    12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
  • Risk Statements: S36
  • Molecular Formula: C18H20N2O6
  • Molecular Structure:CAS No:39562-70-4 5-O-ethyl 3-O-methyl<br />2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 5-O-ethyl 3-O-methyl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Nitrendipine
CAS Registry Number: 39562-70-4
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
Synonyms: ethyl 1,4-dihydro-5-(acetoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate; 3-ethyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Manufacturers' Codes: Bay e 5009
Trademarks: Bayotensin (Bayer); Baypress (Bayer); Bylotensin (Yoshitomi); Deiten (ABC); Nidrel (Specia)
Molecular Formula: C18H20N2O6
Molecular Weight: 360.36
Percent Composition: C 59.99%, H 5.59%, N 7.77%, O 26.64%
Literature References: Dihydropyridine calcium channel blocker. Prepn: H. Meyer et al., DE 2117571; eidem, US 3799934 (1972, 1974 both to Bayer); eidem, Arzneim.-Forsch. 31, 407 (1981). Series of articles on pharmacology: ibid. 2056-2067. Hemodynamic effects: H. O. Ventura et al., Am. J. Cardiol. 51, 783 (1983). Pharmacokinetics: L. Hansson et al., Hypertension 5, Suppl. II, II-25 (1983). HPLC determn in human serum: R. A. Janis et al., J. Clin. Pharmacol. 23, 266 (1983). Double-blind, controlled clinical trial: U. Brugmann et al., Herz 10, 53 (1985). Symposium on pharmacology and clinical efficacy: J. Cardiovasc. Pharmacol. 6 Suppl. 7, S929-S1113 (1984). Toxicology studies: K. Hoffmann, "Toxicological Studies with Nitrendipine" in Nitrendipine, A. Scriabine et al., Eds. (Urban & Schwarzenberg, Baltimore, 1984) pp 25-32. Review: A. Scriabine et al., "Nitrendipine" in New Drugs Annual: Cardiovascular Drugs Vol. 2, A. Scriabine, Ed. (Raven Press, New York, 1984) pp 37-49.
Properties: Crystals from ethanol, mp 158°. Relatively insol in water. LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann).
Melting point: mp 158°
Toxicity data: LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.