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CAS No 39492-01-8 , Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester

  • Name: Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester
  • Synonyms: Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester; p-Carbethoxyphenyl e-guanidinocaproate;Gabexate;p-Carbethoxyphenyl e-guanidineocaproate;
  • CAS Registry Number:
  • Flash Point: 261.4°C
  • Boiling Point: 508.6°Cat760mmHg
  • Density: 1.2g/cm3
  • Flash Point: 261.4°C
  • Molecular Weight: 321.37
  • InChI: InChI=1/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)
  • Molecular Formula: C16H23 N3 O4
  • Molecular Structure:CAS No:39492-01-8 Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester

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39492-01-8 Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester

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39492-01-8 Gabexate

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39492-01-8 GABEXATE MESYLATE

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39492-01-8 GABEXATE MESYLATE

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39492-01-8 Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester

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39492-01-8 Gabexate mesilate

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39492-01-8 GABEXATE

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References of Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester
Title: Gabexate
CAS Registry Number: 39492-01-8
CAS Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]benzoic acid ethyl ester
Synonyms: p-hydroxybenzoic acid ethyl ester 6-guanidinohexanoate; p-carbethoxyphenyl e-guanidinocaproate
Molecular Formula: C16H23N3O4
Molecular Weight: 321.37
Percent Composition: C 59.80%, H 7.21%, N 13.08%, O 19.91%
Literature References: Non-peptide proteolytic enzyme inhibitor which also inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, trypsin but not chymotrypsin; cf. aprotinin. Prepn as the p-toluenesulfonate salt: S. Fujii, T. Watanabe, DE 2050484; eidem, US 3751447 (1971, 1973 both to Ono). Enzyme inhibition: M. Muramatu, S. Fujii, Biochim. Biophys. Acta 268, 221 (1972); S. Tamura et al., ibid. 484, 417 (1977). Pharmacology: T. Okegada et al., Nippon Yakurigaku Zasshi 71, 71 (1975), C.A. 84, 218m (1976). Metabolism: M. Sugiyama et al., Oyo Yakuri 9, 733 (1975), C.A. 83, 188145s (1975). Metabolism of inhibitory effect on platelet aggregation: G. Kosaki et al., Thromb. Res. 20, 587 (1980). Beneficial action in traumatic shock: A. M. Lefer et al., IRCS Med. Sci. Libr. Compend. 8, 278 (1980); in exptl acute pancreatitis: J. R. Wisner et al., Pancreas 2, 181 (1987). Comparative clinical study in acute pancreatitis: N. Tanaka et al., Adv. Exp. Med. Biol. 120, 367 (1979). Teratology and toxicity study: T. Fujita et al., Oyo Yakuri 9, 743 (1975), C.A. 83, 188322x (1975).
 
Derivative Type: Methanesulfonate
CAS Registry Number: 56974-61-9
Synonyms: Gabexate mesylate
Trademarks: FOY (Ono); Megacert (Wakamoto)
Molecular Formula: C16H23N3O4.CH3SO3H
Molecular Weight: 417.48
Percent Composition: C 48.91%, H 6.52%, N 10.07%, O 26.83%, S 7.68%
Properties: White crystals. Sol in water, ethanol, chloroform. Slightly sol in acetone. Practically insol in ether. pH of soln (1:100): 4.0-5.0. LD50 in mice (mg/kg): 8000 orally; 4700 s.c.; 25 i.v. (Fujita).
Toxicity data: LD50 in mice (mg/kg): 8000 orally; 4700 s.c.; 25 i.v. (Fujita)
 
Therap-Cat: Enzyme inhibitor (proteinase).
Keywords: Protease Inhibitor.