Home > Name List By 8 > 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R...

CAS No 38966-21-1 , 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-

  • Name: 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
  • Synonyms: Aphidicolin; NSC 234714;8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-;9,15-Cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol,3,17-dihydroxy-4-methyl-, (3a,4a,5a,17a)-;8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, [3R-(3a,4a,4aa,6ab,8b,9b,11ab,11bb)]-; ICI 69653; (+)-Aphidicolin;
  • CAS Registry Number:
  • Density: 1.22 g/cm3
  • Refractive index: 1.586
  • Safety Statements: 22-24
  • Molecular Weight: 338.48
  • InChI: InChI=1/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
  • Molecular Formula: C20H34 O4
  • Molecular Structure:CAS No:38966-21-1 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
Search by region :

Select to

38966-21-1 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-

  • We produce a wide range of organics, especially fluorine, boronic acids, amino acids, unnatural amino acids, peptide, cross linkers, organocatalysts, chiral building blocks, heterocyclic compounds and other active pharmaceutical ingredients compounds...
  • China Shanghai P&T Fine Chemical Co., Ltd [Manufacturer]
  • Tel: 86-21-12345678
  • Address: Lane No.36, Zhongke Road 2195, Zhangjiang High-tech Park, Pudong New Area Shanghai, China shanghai,ShanghaiChina
Contact Supplier

38966-21-1 APHIDICOLIN

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
Contact Supplier

38966-21-1 Aphidicolin

  • Aphidicolin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
Contact Supplier

38966-21-1 Aphidicolin

  • Aphidicolin, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
Contact Supplier

38966-21-1 Aphidicolin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
Contact Supplier

38966-21-1 Aphidicolin

Contact Supplier

38966-21-1 Aphidicolin

  • China Haihang Industry Co., Ltd. []
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, ,China
Contact Supplier

38966-21-1 SC-201535 APHIDICOLIN

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
  • Fax: 831-457-3801
  • Address: Santa Cruz Biotechnology, Inc.
    2145 Delaware Ave.
    Santa Cruz, CA 95060 ,United States
Contact Supplier

38966-21-1 Aphidicolin

  • Aphidicolin
  • Germany IRIS Biotech GmbH [Manufacturer]
  • Tel: +49 9231 9619 73
  • Fax: +49 9231 9619 99
  • Address: IRIS Biotech GmbH
    Waldershofer Str. 49-51
    D-95615 Marktredwitz, Germany ,Germany
Contact Supplier

38966-21-1 Aphidicolin, 99%

  • Aphidicolin, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
Contact Supplier

Select to

References of 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
Title: Aphidicolin
CAS Registry Number: 38966-21-1
CAS Name: (3a,4a,5a,17a)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Synonyms: tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Manufacturers' Codes: ICI-69653; NSC-234714
Molecular Formula: C20H34O4
Molecular Weight: 338.48
Percent Composition: C 70.97%, H 10.12%, O 18.91%
Literature References: Novel tetracyclic diterpene antibiotic with antiviral and antimitotic properties, isolated as (+)-form from Cephalosporium aphidicola Petch. Specific inhibitor of DNA a-polymerase. Description and x-ray crystallographic determn of structure: K. M. Brundret et al., Chem. Commun. 1972, 1027. Prepn and antiviral activity: A. Borrow et al., US 3761512 (1973 to ICI). Structure and abs config: W. Dalziel et al., J. Chem. Soc. Perkin Trans. 1 1973, 2841. Total synthesis of (±)-aphidicolin: B. M. Trost et al., J. Am. Chem. Soc. 101, 1328 (1979); J. E. McMurry et al., ibid. 1331; E. J. Corey et al., ibid. 102, 1743 (1980); J. E. McMurry et al., Tetrahedron 37, Suppl. 1, 319 (1981). Antiviral effects in vitro and in vivo: R. A. Bucknall et al., Antimicrob. Agents Chemother. 4, 294 (1973). Antimitotic activity: S. Ikegami et al., Nature 275, 458 (1978). Effects on DNA synthesis in mouse sarcoma: S. Seki et al., Biochim. Biophys. Acta 610, 413 (1980). Enzymatic determn method: G. Pedrali-Noy et al., J. Biochem. Biophys. Methods 4, 113 (1981). Induction of differentiation of human myeloid leukemia cells: J. Griffin et al., Exp. Hematol. 10, 774 (1982). Effects on cell proliferation: G. Iliakis et al., Int. J. Radiat. Biol. 42, 417 (1982); on g-irradiated human fibroblasts: P. J. Smith, M. C. Paterson, Biochim. Biophys. Acta 739, 17 (1983).
Properties: Needles from ethyl acetate, mp 227-232°. [a]D27 +12° (c = 1 in methanol).
Melting point: mp 227-232°
Optical Rotation: [a]D27 +12° (c = 1 in methanol)
 
Derivative Type: (±)-Form
Properties: White cryst, mp 218-220°.
Melting point: mp 218-220°
 
Use: As a biological tool in studies of cell proliferation and differentiation.