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CAS No 38748-32-2 , Triptolide

  • Name: Triptolide
  • Synonyms: Triptolide;Triptolide 95%;
  • CAS Registry Number:
  • Density: 1.48 g/cm3
  • Refractive index: 1.647
  • Water Solubility: DMSO: soluble
  • Safety Statements: Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Molecular Weight: 360.41
  • InChI: InChI=1/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
  • Molecular Formula: C20H24O6
  • Molecular Structure:CAS No:38748-32-2 Triptolide

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38748-32-2 SC-200122 TRIPTOLIDE (PG490)

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
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  • China Guilin Sanleng Biotech Co. Ltd. [Manufacturers]
  • Tel: +86-773-2636208
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  • Address: 9, Building 12, Guibei Shangmaocheng, Balijie Economic Development Area, Guilin City, Guangxi Prov., China. Guilin,GuangxiChina
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References of Triptolide
Title: Triptolide
CAS Registry Number: 38748-32-2
CAS Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Synonyms: PG490
Molecular Formula: C20H24O6
Molecular Weight: 360.40
Percent Composition: C 66.65%, H 6.71%, O 26.64%
Literature References: Diterpenoid triepoxide with immunosuppressant and antitumor properties; isolated from the Chinese medicinal herb, Tripterygium wilfordii Hook. f., Celastraceae. Isoln and structure determn: S. M. Kupchan et al., J. Am. Chem. Soc. 94, 7194 (1972). Synthesis of racemate: R. S. Buckanin et al., ibid. 102, 1200 (1980); of naturally occurring (-)-form: D. Yang et al., ibid. 121, 5579 (1999). HPLC and SPE determn in Tripterygium root extracts: A. M. Brinker, I. Raskin, J. Chromatogr. A 1070, 65 (2005). Animal studies of male antifertility effects: A. P. S. Hikim et al., J. Androl. 21, 431 (2000); P. N. Huynh et al., ibid. 689. Mechanistic studies of apoptotic and antitumor activities: W.-T. Chang et al., J. Biol. Chem. 276, 2221 (2001); T. M. Kiviharju et al., Clin. Cancer Res. 8, 2666 (2002); S. J. Leuenroth, C. M. Crews, Chem. Biol. 12, 1259 (2005). Review of anti-inflammatory and immunosuppressive properties: B. J. Chen, Leuk. Lymphoma 42, 253-265 (2001).
Properties: mp 226-227°. [a]D25 -154° (c = 0.369 in CH2Cl2). uv max (ethanol): 218 nm (e 14000). Sol in DMSO, ethanol. LD50 i.p. in mice: 1.93 mg/kg (Chen).
Melting point: mp 226-227°
Optical Rotation: [a]D25 -154°
Absorption maximum: uv max (ethanol): 218 nm (e 14000)
Toxicity data: LD50 i.p. in mice: 1.93 mg/kg (Chen)
 
Derivative Type: 14-Succinyl triptolide sodium salt
CAS Registry Number: 195883-09-1
Synonyms: PG490-88
Molecular Formula: C24H27NaO9
Molecular Weight: 482.46
Percent Composition: C 59.75%, H 5.64%, Na 4.77%, O 29.85%
Literature References: Semi-synthetic water soluble prodrug. Prepn: Y. M. Qi, J. H. Musser, US 5663335 (1997 to Pharmagenesis). Animal model studies of prevention of graft-vs-host disease: B. J. Chen et al., Transplantation 70, 1442 (2000); of antitumor effects: J. M. Fidler et al., Mol. Cancer Ther. 2, 855 (2003); of allograft survival in organ transplantation: F. Pan et al., Transplant. Proc. 37, 134 (2005).