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CAS No 38398-32-2 , Pregnan-20-one,3-hydroxy-3-methyl-, (3a,5a)-

  • Name: Pregnan-20-one,3-hydroxy-3-methyl-, (3a,5a)-
  • Synonyms: CCD 1042;Ganaxolone; 5a-Pregnan-20-one, 3a-hydroxy-3-methyl-;3a-Hydroxy-3b-methyl-5a-pregnan-20-one;Pregnan-20-one,3-hydroxy-3-methyl-, (3a,5a)-;
  • CAS Registry Number:
  • Flash Point: 185.4°C
  • Boiling Point: 434.8°Cat760mmHg
  • Density: 1.036g/cm3
  • Refractive index: 1.517
  • Safety Statements:
    Safety Statements 22-24/25
    RTECS TU4384700
  • Flash Point: 185.4°C
  • Molecular Weight: 0
  • InChI: InChI=1/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
  • Molecular Formula: C22H36 O2
  • Molecular Structure:CAS No:38398-32-2 Pregnan-20-one,3-hydroxy-3-methyl-, (3a,5a)-

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38398-32-2 2531 GANAXOLONE

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38398-32-2 GANAXOLONE

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References of Pregnan-20-one,3-hydroxy-3-methyl-, (3a,5a)-
Title: Ganaxolone
CAS Registry Number: 38398-32-2
CAS Name: (3a,5a)-3-Hydroxy-3-methylpregnan-20-one
Manufacturers' Codes: CCD-1042
Molecular Formula: C22H36O2
Molecular Weight: 332.52
Percent Composition: C 79.46%, H 10.91%, O 9.62%
Literature References: Synthetic analog of the neuroactive steroids known as epalons that allosterically modulate the g-aminobutyric acid type A (GABAA) receptor. Prepn: M. C. Cook et al., DE 2162555; eidem, US 3953429 (1972, 1976 both to Glaxo); D. J. Hogenkamp et al., J. Med. Chem. 40, 61 (1997). Binding study and anticonvulsant activity: R. B. Carter et al., J. Pharmacol. Exp. Ther. 280, 1284 (1997). Clinical pharmacology: E. P. Monaghan et al., Epilepsia 38, 1026 (1997). Determn in serum by HPLC-MS-MS: K. Ramu et al., J. Chromatogr. B 751, 49 (2001).
Properties: White crystals from methanol, mp 190-192°. [a]D +103°. Insol in aqueous media.
Melting point: mp 190-192°
Optical Rotation: [a]D +103°
Therap-Cat: Anticonvulsant; antimigraine.
Keywords: Anticonvulsant; Antimigraine.