Home > Name List By n > N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine

CAS No 37640-71-4 , N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine

  • Name: N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine
  • Synonyms: Aspenon; Aprindin; Aprindinum [INN-Latin]; Fibocil;N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine; Aprindina; Aprindinum; Aprindina [INN-Spanish];Aprinidine;
  • CAS Registry Number:
  • Flash Point: 202°C
  • Boiling Point: 450.9°Cat760mmHg
  • Density: 1.046g/cm3
  • Refractive index: 1.588
  • Flash Point: 202°C
  • Molecular Weight: 322.487
  • InchiKey: NZLBHDRPUJLHCE-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-
    8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3
  • Molecular Formula: C22H30N2
  • Molecular Structure:CAS No:37640-71-4 N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine

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References of N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine
Title: Aprindine
CAS Registry Number: 37640-71-4
CAS Name: N-(2,3-Dihydro-1H-inden-2-yl)-N￠,N￠-diethyl-N-phenyl-1,3-propanediamine
Synonyms: N,N-diethyl-N￠-2-indanyl-N￠-phenyl-1,3-propanediamine; N-[3-(diethylamino)propyl]-N-phenyl-2-indanamine
Manufacturers' Codes: compd 99170; AC-1802; Lilly 99170
Molecular Formula: C22H30N2
Molecular Weight: 322.49
Percent Composition: C 81.94%, H 9.38%, N 8.69%
Literature References: Membrane-stabilizing agent. Prepn: P. M. Vanhoof, P. M. Clarebout, BE 760018; eidem, US 3923813 (1971, 1975 both to Christiaens). Toxicological study: A. Georges et al., Arzneim.-Forsch. 23, 519 (1973). Pharmacokinetics: T. Kobari et al., Eur. J. Clin. Pharmacol. 26, 129 (1984). HPLC determn in plasma: T. Kobari et al., J. Chromatogr. 278, 220 (1983). Clinical studies: D. P. Zipes et al., Am. J. Cardiol. 40, 586 (1977); P. J. Troup, D. P. Zipes, Am. Heart J. 97, 322 (1979). Reviews: P. Danilo, ibid. 119; I. Stoel, S. F. Hagemeijer, Eur. Heart J. 1, 147 (1980).
 
Derivative Type: Hydrochloride
CAS Registry Number: 33237-74-0
Manufacturers' Codes: Compd 83846
Trademarks: Amidonal (PCR Arzneimittel); Aspenon (Mitsui); Fiboran (Christiaens); Ritmusin (Gebro)
Molecular Formula: C22H30N2.HCl
Molecular Weight: 358.95
Percent Composition: C 73.61%, H 8.70%, N 7.80%, Cl 9.88%
Properties: Crystals from benzene, mp 120-121°.
Melting point: mp 120-121°
 
Therap-Cat: Antiarrhythmic (class I).
Keywords: Antiarrhythmic.