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CAS No 37321-09-8 , Apramycin

  • Name: Apramycin
  • Synonyms: Apralan solubile; Apralin;Nebramycin factor 2;Pyrano[3,2-b]pyran,D-streptamine deriv.;Apramycin; Ambylan; Apralan 200 Injection; Apramycin; EL 857; Nebramycin II; EL 857/820; Apralan; Apralan Soluble;
  • CAS Registry Number:
  • Density: 1.56 g/cm3
  • Refractive index: 1.657
  • Safety Statements: When heated to decomposition it emits acrid smoke and irritating fumes.
  • EINECS: 253-460-1
  • Molecular Weight: 539.579
  • InChI: InChI=1/C21H41N5O11/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31/h5-21,26-32H,2-4,22-25H2,1H3/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19?,20-,21-/m1/s1
  • Molecular Formula: C21H41N5O11
  • Molecular Structure:CAS No:37321-09-8 Apramycin

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37321-09-8 Apramycin

  • Apramycin
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37321-09-8 Apramycin

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37321-09-8 Apramycin

  • Apramycin, 623 units/mg
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
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37321-09-8 Apramycin

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  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
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37321-09-8 APRAMYCIN

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
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  • United States LKT Laboratories, Inc [Manufacturer]
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References of Apramycin
Title: Apramycin
CAS Registry Number: 37321-09-8
CAS Name: O-4-Amino-4-deoxy-a-D-glucopyranosyl-(1?8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-a-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1?4)-2-deoxy-D-streptamine
Synonyms: 4-O-[3a-amino-6a-[(4-amino-4-deoxy-a-D-glucopyranosyl)oxy]-2,3,4,4ab,6,7,8aa-octahydro-8b-hydroxy-7b-(methylamino)pyranopyrano[3,2-b]pyran-2a-yl]-2-deoxy-D-streptamine; nebramycin factor 2
Manufacturers' Codes: EL-857; EL-857/820; 47657
Trademarks: Apralan (Elanco)
Molecular Formula: C21H41N5O11
Molecular Weight: 539.58
Percent Composition: C 46.74%, H 7.66%, N 12.98%, O 32.62%
Literature References: Broad spectrum aminocyclitol antibiotic and component of the nebramycin complex, produced by a strain of Streptomyces tenebrarius: R. Q. Thompson, E. A. Presti, Antimicrob. Agents Chemother. 1967, 332; W. M. Stark, US 3691279 (1972 to Lilly). Structure, abs config and properties: S. O'Connor et al., J. Org. Chem. 41, 2087 (1976). 13C-NMR: E. Wenkert, E. W. Hagaman, ibid. 701. In vitro activity: R. Ryden et al., J. Antimicrob. Chemother. 3, 609 (1977). Synthetic studies: H. C. Jarrell, W. A. Szarek, Carbohydr. Res. 67, 43 (1978); eidem, Can. J. Chem. 56, 144 (1978); 57, 924 (1979). See also tobramycin.
 
Derivative Type: Monohydrate
Properties: From aqueous ethanol, mp 245-247°. pKa (H2O): 8.5, 7.8, 7.2, 6.2, 5.4. Very soluble in water; slightly sol in lower alcohols.
Melting point: mp 245-247°
pKa: pKa (H2O): 8.5, 7.8, 7.2, 6.2, 5.4
 
Therap-Cat-Vet: Antibacterial.