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CAS No 37091-66-0 , Azlocillin

  • Name: Azlocillin
  • Synonyms: 3,3-Dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Azlocillin;
  • CAS Registry Number:
  • Density: 1.55g/cm3
  • Refractive index: 1.696
  • EINECS: 253-348-2
  • Molecular Weight: 461.49
  • InChI: InChI=1/C20H23N5O6S/c1-20(2)13(17(28)29)25-15(27)12(16(25)32-20)22-14(26)11(10-6-4-3-5-7-10)23-19(31)24-9-8-21-18(24)30/h3-7,11-13,16H,8-9H2,1-2H3,(H,21,30)(H,22,26)(H,23,31)(H,28,29)/t11?,12-,13+,16-/m1/s1
  • Molecular Formula: C20H23N5O6S
  • Molecular Structure:CAS No:37091-66-0 Azlocillin

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References of Azlocillin
Title: Azlocillin
CAS Registry Number: 37091-66-0
CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[[(2R)-[[(2-oxo-1-imidazolidinyl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms: D-a-[(imidazolidin-2-on-1-yl)carbonylamino]benzylpenicillin
Manufacturers' Codes: Bay e 6905
Molecular Formula: C20H23N5O6S
Molecular Weight: 461.49
Percent Composition: C 52.05%, H 5.02%, N 15.18%, O 20.80%, S 6.95%
Literature References: Semi-synthetic, broad-spectrum acylureido penicillin. Prepn: H. Disselnkotter, K. G. Metzger, FR 2100682; eidem, US 3933795 (1971, 1976 both to Bayer); H. B. Konig et al., Eur. J. Med. Chem. - Chim. Ther. 17, 59 (1982). In vitro studies: D. Stewart et al., Antimicrob. Agents Chemother. 11, 865 (1977). In vitro and in vivo activity: G. K. Daikos et al., Curr. Chemother., Proc. 10th Int. Congr. Chemother., 1977 (Amer. Soc. Microbiol., Washington, D.C., 1978) 1, pp 626-8. Pharmacokinetics: P. Fiegel, K. Becker, Antimicrob. Agents Chemother. 14, 288 (1978). Comparison with other penicillins: J. M. Andrews, K. A. Bedford, ibid. 559. Clinical studies: H. Lode et al., Infection 5, 163 (1977); E. B. Helm et al., Dtsch. Med. Wochenschr. 102, 1211 (1977). Series of articles on antibacterial activity, pharmacology, and clinical trials: Arzneim.-Forsch. 29, 1915-2032 (1979); Infection 10, Suppl. 3, S121-S266 (1982); J. Antimicrob. Chemother. 11, Suppl. B, 1-239 (1983).
 
Derivative Type: Sodium salt
CAS Registry Number: 37091-65-9
Trademarks: Azlin (Bayer); Securopen (Bayer)
Molecular Formula: C20H22N5NaO6S
Molecular Weight: 483.47
Percent Composition: C 49.69%, H 4.59%, N 14.49%, Na 4.76%, O 19.86%, S 6.63%
Properties: Pale yellow crystals, sol in water, methanol, DMF. Slightly sol in ethanol, isopropanol.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.