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CAS No 36894-69-6 , 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide

  • Name: 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
  • Synonyms: Ibidomide; Labetalolum [INN-Latin]; Albetol; Trandate; AH 5158; Labetalolum;2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; 36894-69-6; Normodyne;Labetolol;
  • CAS Registry Number:
  • Density: 1.2 g/cm3
  • Refractive index: 1.609
  • EINECS: 253-258-3
  • Molecular Weight: 328.40546
  • InchiKey: SGUAFYQXFOLMHL-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)
    16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
  • Molecular Formula: C19H24N2O3
  • Molecular Structure:CAS No:36894-69-6 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
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36894-69-6 Labetalol

  • IUPAC NAME-(RS)-2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide MOLECULAR FORMULA-C19H24N2O3 MOLAR MASS-328.406 g/mol Labetalol (Normodyne, Trandate) is a mixed alpha/beta adrenergic antagonist, which is used to treat high bl...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
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  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

36894-69-6 Labetalol

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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36894-69-6 Labetalol

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China ,China
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36894-69-6 Labetalol

  • Hong kong Achemo Sientific cooperation [Manufacturers]
  • Tel: 00852-39711547
  • Fax: 00852-39711547
  • Address: 38 Plaza,38 Shantung street,MongKoK,kowloon,Hongkong Kowloon,KowloonHong kong
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36894-69-6 Labetalol

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36894-69-6 Labetalol

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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36894-69-6 Labetalol

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 ,China
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36894-69-6 Labetalol

  • Hong kong LEO CHEMICAL (HONG KONG) CO., LTD [Manufacturer]
  • Tel: 86-519-85098858/ 86-519-85098877
  • Fax: 86-519-85098888/8889
  • Address: Hong Kong Office :
    LEO CHEMICAL (HONG KONG) CO., LTD
    MNJ2070, RM1602,
    OMEGA PLAZA, 32 DUNDAS STREET,
    MONKOK, KL, HONG KONG ,Hong kong
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36894-69-6 Labetalol

  • China Luna Chemicals Co.,Ltd. []
  • Fax: +86-571-85775960
  • Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China ,China
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36894-69-6 LABETALOL

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References of 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
Title: Labetalol
CAS Registry Number: 36894-69-6
CAS Name: 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide
Synonyms: 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]salicylamide; ibidomide
Molecular Formula: C19H24N2O3
Molecular Weight: 328.41
Percent Composition: C 69.49%, H 7.37%, N 8.53%, O 14.62%
Literature References: Specific competitive antagonist at both a- and b-adrenergic receptor sites. Prepn: L. H. Lunts, D. T. Collin, DE 2032642; eidem, US 4012444 (1971, 1977 both to Allen & Hanburys). Synthesis of labetalol and enantiomers: J. E. Clifton et al., J. Med. Chem. 25, 670 (1982); and comparison of cardiovascular properties: E. H. Gold et al., ibid. 1363. Abs config of dilevalol: P. Murray-Rust et al., Acta Crystallogr. C40, 825 (1984). Adrenoceptor blocking properties: E. J. Sybertz et al., J. Pharmacol. Exp. Ther. 218, 435 (1981). HPLC determn in serum or plasma: T. F. Woodman, B. Johnson, Ther. Drug Monit. 3, 371 (1981). Metabolism in animals and man: R. Hopkins et al., Biochem. Soc. Trans. 4, 726 (1976). Toxicity: K. Shimpo et al., Hokkaido Igaku Zasshi 53, 15 (l978), C.A. 90, 66465v (1974). Review of pharmacology: R. Donnelly, G. J. A. Macphee, Clin. Pharmacokinet. 21, 95-109 (1991); of therapeutic applications in hypertension and ischemic heart disease: K. L. Goa et al., Drugs 37, 583-627 (1989).
 
Derivative Type: Hydrochloride
CAS Registry Number: 32780-64-6
Manufacturers' Codes: AH-5158A; Sch-15719W
Trademarks: Amipress (Dox-Al); Ipolab (Finmedical); Labelol (ELEA); Labrocol (Lagap); Normodyne (Schering); Presdate (Alfa); Pressalolo (Locatelli); Trandate (Allen & Hanburys)
Molecular Formula: C19H24N2O3.HCl
Molecular Weight: 364.87
Percent Composition: C 62.54%, H 6.91%, N 7.68%, O 13.15%, Cl 9.72%
Properties: White crystalline solid from ethanol-ethyl acetate, mp 187-189°. Sol in water, ethanol. Insol in ether, chloroform. LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo).
Melting point: mp 187-189°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo)
 
Derivative Type: (R,R)-Form hydrochloride
CAS Registry Number: 75659-08-4; 75659-07-3 (free base)
Synonyms: Dilevalol hydrochloride
Manufacturers' Codes: Sch-19927
Properties: Polymorphic crystals from ethanol, mp 133-134° (dec); mp 192-193.5° (dec). [a]D26 -30.6° (c = 1.0 in ethanol).
Melting point: mp 133-134° (dec); mp 192-193.5° (dec)
Optical Rotation: [a]D26 -30.6° (c = 1.0 in ethanol)
 
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Blocker; ?Adrenergic Blocker; Antihypertensive; Arylethanolamine Derivatives.