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CAS No 36703-88-5 , 4-acetamidobenzoic
acid

  • Name: 4-acetamidobenzoic
    acid
  • Synonyms: Isoprinosin; INOSINE PRANOBEX; Isoviral; Aviral;Inosiplex; Isoprinosine;9-[(2R,3R,4S,5R)-3,
    4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; Isoprinosina;1-
    (dimethylamino)propan-2-ol; Viruxan; Delimmun; Methisoprinol;4-acetamidobenzoic
    acid;
  • CAS Registry Number:
  • Density: g/cm3
  • EINECS: 253-162-1
  • Molecular Weight: 1115.23252
  • InchiKey: YLDCUKJMEKGGFI-QCSRICIXSA-N
  • InChI: InChI=1S/C10H12N4O5.3C9H9NO3.3C5H13NO/c15-1-4-6(16)7(17)10(19-4)14-3-13-
    5-8(14)11-2-12-9(5)18;3*1-6(11)10-8-4-2-7(3-5-8)9(12)13;3*1-5(7)4-6(2)3/
    h2-4,6-7,10,15-17H,1H2,(H,11,12,18);3*2-5H,1H3,(H,10,11)(H,12,13);3*5,
    7H,4H2,1-3H3/t4-,6-,7-,10-;;;;;;/m1....../s1
  • Molecular Formula: C52H78N10O17
  • Molecular Structure:CAS No:36703-88-5 4-acetamidobenzoic<br />acid

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36703-88-5 Inosine Pranobex

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References of 4-acetamidobenzoic
acid
Title: Inosine Pranobex
CAS Registry Number: 36703-88-5
CAS Name: Inosine mono[4-(acetylamino)benzoate] (salt) compd with 1-(dimethylamino)-2-propanol (1:3)
Synonyms: inosine:dimethylaminoisopropanol acetamidobenzoate (1:3); inosiplex; methisoprinol
Manufacturers' Codes: NP-113; NPT-10381
Trademarks: Aviral (Medici Domus); Delimmun (Newport); Imunoviral (Newport); Isoprinosin (Newport); Isoprinosina (Newport); Isoprinosine (Newport); Isoviral (Lenza); Modimmunal (Ravizza); Pranosina (Newport); Pranosine (Newport); Viruxan (Newport)
Molecular Formula: C52H78N10O17
Molecular Weight: 1115.23
Percent Composition: C 56.00%, H 7.05%, N 12.56%, O 24.39%
Literature References: Immunostimulant complex formed from the p-acetamidobenzoate salt of dimethylaminoisopropanol and inosine in a 3:1 molar ratio. Prepn: P. Gordon, DE 1965431; idem, US 3646007 (1971, 1972 both to Newport Pharm.). Antiviral activity: E. R. Brown, P. Gordon, Can. J. Microbiol. 18, 1463 (1972); R. L. Muldoon et al., Antimicrob. Agents Chemother. 2, 224 (1972). Stimulatory effect on T-cell function: L. Binderup, Int. J. Immunopharmacol. 7, 93 (1985). Pharmacology and therapeutic potential: D. M. Campoli-Richards et al., Drugs 32, 383 (1986). Clinical immunopharmacology: A. J. Glasky, J. F. Gordon, Cancer Detect. Prev. Suppl. 1, 597 (1987). Clinical trial in subacute sclerosing panencephalitis (SSPE): C. E. Jones et al., Lancet 1, 1034 (1982); G. Gascon et al., Brain Dev. 15, 346 (1993). Clinical trial in pre-AIDS patients: C. Pedersen et al., N. Engl. J. Med. 322, 1757 (1990). Review of efficacy in HIV infection: C. De Simone et al., Int. J. Immunopharmacol. 13, Suppl. 1, 19-27 (1991).
Properties: Neutral water-soluble solid. LD50 in mice and rats (mg/kg): >4000 orally and i.p. (Gordon).
Toxicity data: LD50 in mice and rats (mg/kg): >4000 orally and i.p. (Gordon)
Therap-Cat: Immunomodulator; antiviral.
Keywords: Antiviral; Purines/Pyrimidinones; Immunomodulator.