CAS No 362-29-8 , 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

Name: 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
Synonyms: Propiomazinum;1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one; Propiomazinum [INN-Latin]; Propiomazina [INN-Spanish]; Propiomazina; Propionylpromethazine; Largon;Phenoctyl; Wy-1359;
CAS Registry Number:362-29-8
Flash Point: 256.7°C
Boiling Point: 500.8°Cat760mmHg
Density: 1.137g/cm³
Flash Point: 256.7°C
EINECS: 206-646-1
Molecular Weight: 340.48236
InchiKey: UVOIBTBFPOZKGP-UHFFFAOYSA-N
InChI: InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)
16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
Molecular Formula: C₂₀H₂₄N₂OS
Molecular Structure:

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References of 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one

Title: Propiomazine
CAS Registry Number: 362-29-8
CAS Name: 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone
Synonyms: 10-dimethylaminoisopropyl-2-propionylphenothiazine; propionylpromethazine
Manufacturers' Codes: Wy-1359
Molecular Formula: C20H24N2OS
Molecular Weight: 340.48
Percent Composition: C 70.55%, H 7.10%, N 8.23%, O 4.70%, S 9.42%
Literature References: Prepn: Schmitt et al., Bull. Soc. Chim. Fr. 1957, 1474; Schmitt, FR addn. 71342 (addn. to FR 1176919 to Clin-Byla). Comprehensive description of the hydrochloride: K. B. Crombie, L. F. Cullen, Anal. Profiles Drug Subs. 2, 439-466 (1973). GC determn in plasma and urine: U. Ahs, G. Wickstr?m, J. Chromatogr. 183, 229 (1980). Clinical use as sedative: W. F. Powell et al., Anesth. Analg. 49, 132 (1970); as hypnotic: M. Viukari, P. Miettinen, Neuropsychobiology 12, 134 (1984).
Properties: bp0.5 235-245°.
Boiling point: bp0.5 235-245°

Derivative Type: Maleate
Manufacturers' Codes: CB-1678
Trademarks: Indorm (Wyeth); Propavan (Kabi)
Molecular Formula: C20H24N2OS.C4H4O4
Molecular Weight: 456.55
Percent Composition: C 63.14%, H 6.18%, N 6.14%, O 17.52%, S 7.02%
Properties: Crystals from isopropanol, mp 160-161°.
Melting point: mp 160-161°

Derivative Type: Hydrochloride
CAS Registry Number: 1240-15-9
Trademarks: Largon (Wyeth)
Molecular Formula: C20H24N2OS.HCl
Molecular Weight: 376.94
Percent Composition: C 63.73%, H 6.69%, N 7.43%, O 4.24%, S 8.51%, Cl 9.41%
Properties: Yellow, practically odorless powder. Very soluble in water; freely sol in alcohol. Insol in benzene.

Therap-Cat: Sedative, hypnotic.
Therap-Cat-Vet: Tranquilizer.
Keywords: Sedative/Hypnotic.