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CAS No 357-70-0 , Galanthamine

  • Name: Galanthamine
  • Synonyms: (-)-Galanthamine;Galanthamine; Galanthaminum; Galantamin; Lycoremin; Galantamine; Reminyl; Galantamina; Jilkon; Lycoremine;galanthamine;
  • CAS Registry Number:
  • Melting Point: 119-1210C
  • Density: 1.28 g/cm3
  • Molecular Weight: 287.35354
  • InchiKey: ASUTZQLVASHGKV-JDFRZJQESA-N
  • InChI: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11
    (10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
  • Molecular Formula: C17H21NO3
  • Molecular Structure:CAS No:357-70-0 Galanthamine
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357-70-0 Galanthamine base

  • China Zhejiang Sunrise Fine Chemicals Co.,Ltd [Manufacturers]
  • Tel: 86-574-87970875
  • Fax: 86-574-87970879
  • Address: 22nd Fl.East Sea Sunshine Building No.455 Zhongshan East Rd.Ningbo 315040 China Ningbo,zhejiangChina
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357-70-0 GALANTAMINE HYDROBROMIDE

  • China Aktin Chemicals, Inc. [Manufacturer]
  • Tel: +86-28-85159085
  • Fax: +86-28-85152372
  • Address: Aktin Chemicals, Inc.
    Yongfeng Plaza, No.52,
    Yongfeng Road, Hi-tech Zone,
    Chengdu 610041
    P.R.China null,nullChina
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357-70-0 GALANTHAMINE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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357-70-0 Galanthamine base

  • Czech Republic Atypo spol. s r.o. [Manufacturers]
  • Tel: +420 281002510, 281002511
  • Fax: +420 281002509
  • Address: V ol?inách 2300/75, 100 00 Praha 10 Czech Republic null,nullCzech Republic
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357-70-0 Galanthamine base

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357-70-0 Galanthamine

  • Galanthamine product Name: Galanthamine Synonyms: (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; galanthamine CAS Registry Number: 357-70-0 Molecular Formula: C17H21NO3 Molecular Weight: 287.3535...
  • China Wuhan YuanCheng Gongchuang Technology Co., Ltd. [Manufacturer]
  • Tel: 86-27-88083115
  • Fax: 86-27-88048077
  • Address: 496, Zhongshan Road, Wuchang, Wuhan, China Wuhan,HubeiChina
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357-70-0 Galanthamine base

  • China Taizhou Volsen Chemical Co Ltd [Manufacturer, Trading Company]
  • Tel: 86-576-88869393
  • Fax: 86-576 88869392
  • Address: 1721-1722, Floor 17, Block A, Junyue Building, Jiaojiang District Taizhou,ZhejiangChina
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357-70-0 Galantamine

  • China Knowshine (Shanghai) Pharmachemicals Inc. [Manufacturers]
  • Tel: +86-(21)-51320697
  • Fax: +86-(21)-51320699
  • Address: 1043 Halei Road, Suite 306, Zhangjiang Hi-tech Park, Shanghai 201203, Shanghai,ShanghaiChina
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357-70-0 Galanthamine base

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357-70-0 Galanthamine base

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References of Galanthamine
Title: Galantamine
CAS Registry Number: 357-70-0
CAS Name: (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Synonyms: galanthamine; lycoremine
Molecular Formula: C17H21NO3
Molecular Weight: 287.35
Percent Composition: C 71.06%, H 7.37%, N 4.87%, O 16.70%
Literature References: Selective acetylcholinesterase inhibitor. Isoln from Caucasian snowdrops, Galanthus woronowii Vel., Amaryllidaceae: N. F. Proskurnina, A. P. Yakovleva, J. Gen. Chem. USSR 22, 1899 (1952); from Narcissus spp: Boit et al., Ber. 90, 725, 2197 (1957). Structure work: S. Kobayashi et al., Chem. Ind. (London) 1956, 177. Synthesis and stereochemistry: D. H. R. Barton, G. W. Kirby, Proc. Chem. Soc. London 1960, 392; eidem, J. Chem. Soc. 1962, 806. Asymmetric synthesis of isomers from L-tyrosine: K. Shimizu et al., Heterocycles 8, 277 (1977). Biosynthesis studies: D. H. R. Barton et al., J. Chem. Soc. 1963, 4545; W. D?bke, Heterocycles 6, 551 (1977). Toxicology study: S. L. Friess et al., Toxicol. Appl. Pharmacol. 3, 347 (1961). Clinical pharmacokinetics: U. Bickel et al., Clin. Pharmacol. Ther. 50, 420 (1991). Review of pharmacology: A. L. Harvey, Pharmacol. Ther. 68, 113-128 (1995); of clinical experience in Alzheimer's disease: R. Bullock, Exp. Rev. Neurother. 4, 153-163 (2004); of synthesis and pharmacology: J. Marco-Contelles et al., Chem. Rev. 106, 116-133 (2006).
Properties: Crystals from benzene, mp 126-127°. [a]D20 -118.8° (c = 1.378 in ethanol). Monoacidic base. Fairly sol in hot water; freely sol in alcohol, acetone, chloroform. Less sol in benzene, ether.
Melting point: mp 126-127°
Optical Rotation: [a]D20 -118.8° (c = 1.378 in ethanol)
 
Derivative Type: Hydrochloride
Molecular Formula: C17H21NO3.HCl
Molecular Weight: 323.81
Percent Composition: C 63.06%, H 6.85%, N 4.33%, O 14.82%, Cl 10.95%
Properties: Crystals from water, dec 256-257°. Sparingly sol in cold, more sol in hot water. Very sparingly sol in alcohol, acetone.
 
Derivative Type: Hydrobromide
CAS Registry Number: 1953-04-4
Trademarks: Nivalin (Waldheim); Razadyne (J & J); Reminyl (J & J)
Molecular Formula: C17H21NO3.HBr
Molecular Weight: 368.27
Percent Composition: C 55.44%, H 6.02%, N 3.80%, O 13.03%, Br 21.70%
Properties: Crystals from water, dec 246-247°. [a]D20 -93.1° (c = 0.1015 in 15 ml H2O). Sparingly sol in water. LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess).
Optical Rotation: [a]D20 -93.1° (c = 0.1015 in 15 ml H2O)
Toxicity data: LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)
 
Therap-Cat: Cholinesterase inhibitor.
Keywords: Cholinesterase Inhibitor.