Home > Name List By 6 > 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3, 4-dihydro-1λ

CAS No 346-18-9 , 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,
4-dihydro-1λ

  • Name: 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,
    4-dihydro-1λ
  • Synonyms: P-2525;Renese; Polythiazidum [INN-Latin]; Politiazida; Polythiazidum;6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,
    4-dihydro-1λ Renese (TN); Drenusil;6,2,4-benzothiadiazine-7-sulfonamide; Politiazida [INN-Spanish]; Nephril;
  • CAS Registry Number:
  • Flash Point: 304.7°C
  • Boiling Point: 580.1°Cat760mmHg
  • Density: 1.598g/cm3
  • Refractive index: 1.566
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl−, SOx, F−, and NOx.
  • Flash Point: 304.7°C
  • EINECS: 206-468-4
  • Molecular Weight: 439.88183
  • InchiKey: CYLWJCABXYDINA-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,
    14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,
    (H2,16,19,20)
  • Molecular Formula: C11H13ClF3N3O4S3
  • Molecular Structure:CAS No:346-18-9 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,<br />4-dihydro-1λ

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346-18-9 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide

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References of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,
4-dihydro-1λ
Title: Polythiazide
CAS Registry Number: 346-18-9
CAS Name: 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Synonyms: 2-methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide
Trademarks: Drenusil (Pfizer); Nephril (Pfizer); Renese (Pfizer)
Molecular Formula: C11H13ClF3N3O4S3
Molecular Weight: 439.88
Percent Composition: C 30.03%, H 2.98%, Cl 8.06%, F 12.96%, N 9.55%, O 14.55%, S 21.87%
Literature References: Prepn: J. M. McManus, US 3009911 (1961 to Pfizer). Comprehensive description: T. Negendra Varo Prasad, Anal. Profiles Drug Subs. 20, 665-692 (1991).
Properties: Crystals from isopropanol, mp 202.5°. Sol in methanol and acetone. Practically insol in water and chloroform. Sol in aq solns made alkaline with carbonates or hydroxides of the alkali metals. Rate of decompn increases with increase in pH.
Melting point: mp 202.5°
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.