Home > Name List By 1 > 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3, 4-b]thiophen-4-one China

CAS No 34580-13-7 , 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,
4-b]thiophen-4-one Search by region : China

  • Name: 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,
    4-b]thiophen-4-one
  • Synonyms: Zaditor; Ketotifenum [INN-Latin]; Ketotifeno [INN-Spanish];10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,
    4-b]thiophen-4-one; Ketotiphen;Ketotifene; Ketotiphene; Ketotifene [INN-French];
  • CAS Registry Number:
  • Melting Point: 152-153 °C
  • Flash Point: 249.5°C
  • Boiling Point: 488.9°Cat760mmHg
  • Density: 1.236g/cm3
  • Flash Point: 249.5°C
  • EINECS: 252-099-7
  • Molecular Weight: 309.42526
  • InchiKey: ZCVMWBYGMWKGHF-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-
    16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
  • Molecular Formula: C19H19NOS
  • Molecular Structure:CAS No:34580-13-7 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,<br />4-b]thiophen-4-one

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References of 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,
4-b]thiophen-4-one
Title: Ketotifen
CAS Registry Number: 34580-13-7
CAS Name: 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
Molecular Formula: C19H19NOS
Molecular Weight: 309.43
Percent Composition: C 73.75%, H 6.19%, N 4.53%, O 5.17%, S 10.36%
Literature References: Prepn: J. P. Bourquin et al., DE 2111071; eidem, US 3682930 (1971, 1972 both to Sandoz); E. Waldvogel et al., Helv. Chim. Acta 59, 866 (1976). Pharmacology: U. Martin, D. Roemer, Arzneim.-Forsch. 28, 770 (1978). Clinical studies: B. Wüthrick, P. Radielovic, Dtsch. Med. Wochenschr. 103, 1865 (1978); H. Gmür, M. Scherrer, Schweiz. Med. Wochenschr. 109, 881 (1979). Review: U. Martin et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 424-460. Review of clinical experience in asthma and allergy: S. M. Grant et al., Drugs 40, 412-448 (1990).
Properties: Crystals from ethyl acetate, mp 152-153°.
Melting point: mp 152-153°
 
Derivative Type: Fumarate
CAS Registry Number: 34580-14-8
Manufacturers' Codes: HC-20511
Trademarks: Totifen (Chiesi); Zaditen (Novartis); Zaditor (Novartis); Zasten (Novartis)
Molecular Formula: C19H19NOS.C4H4O4
Molecular Weight: 425.50
Percent Composition: C 64.92%, H 5.45%, N 3.29%, O 18.80%, S 7.54%
Properties: Crystals, mp 192° (dec).
Melting point: mp 192° (dec)
 
Therap-Cat: Antiasthmatic; antiallergic.
Keywords: Antiasthmatic (Nonbronchodilator); Antiallergic.