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CAS No 341028-37-3 , 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone

  • Name: 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone
  • Synonyms: CTK7F8125; ALT-711; 341028-37-3; UNII-79QS8K2877; ALT711;Alagebrium chloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone;chloride; CHEMBL2107309; Alagebrium chloride (USAN); AC1L50GX;
  • CAS Registry Number:
  • Molecular Weight: 267.77436
  • InchiKey: MKOMESMZHZNBIZ-UHFFFAOYSA-M
  • InChI: InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/
    h3-7,9H,8H2,1-2H3;1H/q+1;/p-1
  • Molecular Formula: C13H14ClNOS
  • Molecular Structure:CAS No:341028-37-3 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone

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References of 2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone
Title: Alagebrium Chloride
CAS Registry Number: 341028-37-3
CAS Name: 4,5-Dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride
Manufacturers' Codes: ALT-711
Molecular Formula: C13H14ClNOS
Molecular Weight: 267.77
Percent Composition: C 58.31%, H 5.27%, Cl 13.24%, N 5.23%, O 5.98%, S 11.97%
Literature References: Catalytically cleaves crosslinks between advanced glycation end products (AGE) and extracellular matrix proteins. Prepn: A. Cerami et al., EP 808163; eidem, US 5853703 (1997, 1998 both to Alteon; Picower Inst. Med. Res.). In vivo AGE cross-link breaking activity: B. H. R. Wolffenbuttel et al., Proc. Natl. Acad. Sci. USA 95, 4630 (1998). Clinical pharmacology and effect on vascular stiffening: D. A. Kass et al., Circulation 104, 1464 (2001); in elderly patients with heart failure: W. C. Little et al., J. Cardiac Failure 11, 191 (2005). Review of pharmacology and therapeutic potential: S. Vasan et al., Arch. Biochem. Biophys. 419, 89-96 (2003); of clinical evaluations in cardiovascular disease: G. L. Bakris et al., Am. J. Hypertens. 17, 23S-30S (2004).
Therap-Cat: In treatment of cardiovascular complications of diabetes and aging.
Keywords: Antiatherosclerotic.