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CAS No 33765-68-3 , Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-

  • Name: Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-
  • Synonyms: Tsaa 291; NCGC00183854-01; Oxendolona [INN-Spanish]; Oxendolonum [INN-Latin]; 33765-68-3; TSAA-291;Prostetin; Oxendolone [USAN:INN:JAN];Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-;
  • CAS Registry Number:
  • Flash Point: 192.4°C
  • Boiling Point: 451.7°Cat760mmHg
  • Density: 1.1g/cm3
  • Refractive index: 1.553
  • Safety Statements: Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.
  • Flash Point: 192.4°C
  • Molecular Weight: 302.451
  • InchiKey: FCKLFGKATYPJPG-SSTBVEFVSA-N
  • InChI: InChI=1/C20H30O2/c1-3-12-11-18-17-6-4-13-10-14(21)5-7-15(13)16(17)8-9-20(18,2)19(12)22/h10,12,15-19,22H,3-9,11H2,1-2H3/t12-,15-,16+,17+,18-,19-,20-/m0/s1
  • Molecular Formula: C20H30O2
  • Molecular Structure:CAS No:33765-68-3 Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-

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33765-68-3 Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-

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References of Estr-4-en-3-one,16-ethyl-17-hydroxy-, (16b,17b)-
Title: Oxendolone
CAS Registry Number: 33765-68-3
CAS Name: (16b,17b)-16-Ethyl-17-hydroxyestr-4-en-3-one
Synonyms: 16b-ethyl-19-nortestosterone
Manufacturers' Codes: TSAA-291
Trademarks: Prostetin (Takeda)
Molecular Formula: C20H30O2
Molecular Weight: 302.45
Percent Composition: C 79.42%, H 10.00%, O 10.58%
Literature References: Prepn: K. Hiraga et al., DE 2100319; eidem, US 3856829 (1971, 1974 both to Takeda); K. Yoshioka et al., Chem. Pharm. Bull. 23, 3203 (1975). Stereoselective synthesis and NMR study: G. Goto et al., ibid. 25, 1295 (1977). Synthesis and anti-androgenic activity: eidem, ibid. 26, 1718 (1978). Physico-chemical properties and stabilities: K. Itakura et al., Takeda Kenkyushoho 37, 297 (1978), C.A. 91, 20879 (1979). Disposition and metabolism: S. Tanayama et al., Steroids 33, 65 (1979). Series of articles on pharmacology, mechanism of action, anti-androgen effects: Acta Endocrinol. 92 (Suppl 2), 1-107 (1979).
Properties: Crystals from ether, mp 152-153°. [a]D +41° (c = 1.0 in ethanol). uv max (ethanol): 240 nm (e 15800). Stable against heat, humidity, indoor light. Converted to the 16a- and 17a-epimers in sunlight. LD50 in rats, mice (g/kg): >10 orally; 5-10 i.m. and i.p. (Hiraga, 1971).
Melting point: mp 152-153°
Optical Rotation: [a]D +41° (c = 1.0 in ethanol)
Absorption maximum: uv max (ethanol): 240 nm (e 15800)
Toxicity data: LD50 in rats, mice (g/kg): >10 orally; 5-10 i.m. and i.p. (Hiraga, 1971)
Therap-Cat: Anti-androgen; in treatment of benign prostatic hypertrophy.
Keywords: Antiandrogen; Antiprostatic Hypertrophy.