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CAS No 321-64-2 , 1,2,3,4-tetrahydroacridin-9-amine

  • Name: 1,2,3,4-tetrahydroacridin-9-amine
  • Synonyms: Tetrahydroaminocrine;Tetrahydroaminoacridine; Romotal; 321-64-2;1,2,3,4-tetrahydroacridin-9-amine; Cognex; Tetrahydroaminacrine; Tetrahydroaminocrin;
  • CAS Registry Number:
  • Flash Point: 230.5°C
  • Boiling Point: 409.4°Cat760mmHg
  • Density: 1.195g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, and subcutaneous routes. Mutation data reported. Human systemic effects: changes in blood cell count, fatty degeneration, liver function tests impaired. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T
  • Flash Point: 230.5°C
  • EINECS: 206-291-2
  • Molecular Weight: 198.26366
  • InchiKey: YLJREFDVOIBQDA-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,
    7H,2,4,6,8H2,(H2,14,15)
  • Risk Statements: R25;
  • Molecular Formula: C13H14N2
  • Molecular Structure:CAS No:321-64-2 1,2,3,4-tetrahydroacridin-9-amine

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References of 1,2,3,4-tetrahydroacridin-9-amine
Title: Tacrine
CAS Registry Number: 321-64-2
CAS Name: 1,2,3,4-Tetrahydro-9-acridinamine
Synonyms: 9-amino-1,2,3,4-tetrahydroacridine; 5-amino-1,2,3,4-tetrahydroacridine; 1,2,3,4-tetrahydro-5-aminoacridine
Molecular Formula: C13H14N2
Molecular Weight: 198.26
Percent Composition: C 78.75%, H 7.12%, N 14.13%
Literature References: Centrally active anticholinesterase; cognition enhancer. Prepn: Braun et al., Ber. 64, 227 (1931); Albert, Gledhill, J. Soc. Chem. Ind. 64, 169T (1945); Petrow, J. Chem. Soc. 1947, 634; J. A. Moore, L. D. Kornreich, Tetrahedron Lett. 4, 1277 (1963). Pharmacology and toxicity: S. Gershon, F. H. Shaw, J. Pharm. Pharmacol. 10, 638 (1958). Enzyme inhibiting activity: P. N. Kaul, ibid. 14, 243 (1962). Neuropharmacology: B. Drukarch et al., Life Sci. 42, 1011 (1988). Spectrofluorimetric determn in serum: I. Aparico et al., Analyst 123, 1575 (1998). Clinical trial in severe Alzheimer's disease: W. K. Summers et al., N. Engl. J. Med. 315, 1241 (1986). See also: ibid. 316, 1603-1606. Clinical evaluation of reduced mortality in dementia: B. R. Ott, K. L. Lapane, J. Am. Geriatr. Soc. 50, 35 (2002). Review of pharmacology and clinical uses: W. K. Summers et al., Clin. Toxicol. 16, 269-281 (1980); of cholinesterase inhibition in Alzheimer's disease: N. Qizilbash et al., J. Am. Med. Assoc. 280, 1777-1782 (1998).
Properties: Octahedra from very dil alc, mp 183-184°.
Melting point: mp 183-184°
 
Derivative Type: Hydrochloride
CAS Registry Number: 1684-40-8
Trademarks: Cognex (Warner-Lambert); THA (Woods)
Molecular Formula: C13H14N2.HCl
Molecular Weight: 234.72
Percent Composition: C 66.52%, H 6.44%, N 11.93%, Cl 15.10%
Properties: Yellow needles from concd hydrochloric acid, mp 283-284°. Bitter taste. Sol in water. pH of 1.5% soln: 4.5-6. uv max (acetate buffer, pH 1-7): 242 nm. Emission max: 362 nm.
Melting point: mp 283-284°
Absorption maximum: uv max (acetate buffer, pH 1-7): 242 nm
 
Therap-Cat: Nootropic. Antidote to curare. Respiratory stimulant.
Keywords: Antidote (Curare); Cholinesterase Inhibitor; Nootropic; Respiratory Stimulant.