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CAS No 32059-15-7 , Guanidine,N-[(octahydro-2-azocinyl)methyl]-

  • Name: Guanidine,N-[(octahydro-2-azocinyl)methyl]-
  • Synonyms: Guanidine,[(octahydro-2-azocinyl)methyl]- (8CI,9CI);Guanidine,N-[(octahydro-2-azocinyl)methyl]-;Guanazodine; a-Guanidinomethylheptamethylenimine; Azocine, guanidine deriv.;
  • CAS Registry Number:
  • Safety Statements: Poison by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Molecular Weight: 184.33
  • InChI: InChI=1S/C9H20N4/c10-9(11)13-7-8-5-3-1-2-4-6-12-8/h8,12H,1-7H2,(H4,10,11,13)
  • Molecular Formula: C9H20 N4
  • Molecular Structure:CAS No:32059-15-7 Guanidine,N-[(octahydro-2-azocinyl)methyl]-

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References of Guanidine,N-[(octahydro-2-azocinyl)methyl]-
Title: Guanazodine
CAS Registry Number: 32059-15-7
CAS Name: [(Octahydro-2-azocinyl)methyl]guanidine
Synonyms: a-guanidinomethylheptamethylenimine; 1-azacyclooct-2-ylmethylguanidine
Molecular Formula: C9H20N4
Molecular Weight: 184.28
Percent Composition: C 58.66%, H 10.94%, N 30.40%
Literature References: Hypotensive agent, related structurally to guanethidine. Prepn of the sulfate salt: J. Rakoczi et al., HU 155990; eidem, US 3856778 (1969, 1974 both to EGYT). Pharmacokinetics in man: T. Past et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 8, 111 (1973). General pharmacology: H. Iwata et al., Oyo Yakuri 14, 235 (1977), C.A. 88, 16070 (1977). Analytical study: E. Zollner-Ivan, Acta Pharm. Hung. 48, 76 (1978). Clinical studies in hypertension: S. Dobi et al., Ther. Hung. 28, 60 (1980); Z. Herpai et al., ibid. 181.
 
Derivative Type: Sulfate monohydrate
Manufacturers' Codes: EGYT-739
Trademarks: Calnegyt (Toyo Jozo); Sanegyt (EGYT)
Molecular Formula: C9H20N4.H2SO4.H2O
Molecular Weight: 300.38
Percent Composition: C 35.99%, H 8.05%, N 18.65%, S 10.67%, O 26.63%
Properties: White crystals from water, mp 239-241°. LD50 in mice (mg/kg): 2450 orally, 700 s.c., 165 i.v. (Rakoczi, 1974).
Melting point: mp 239-241°
Toxicity data: LD50 in mice (mg/kg): 2450 orally, 700 s.c., 165 i.v. (Rakoczi, 1974)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Guanidine Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.