Home > Name List By 1 > 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1, 3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

CAS No 31868-18-5 , 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,
3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

  • Name: 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,
    3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
  • Synonyms: CS-386;10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,
    3]oxazolo[3,2-d][1,4]benzodiazepin-6-one;Melex; Mexazolamum [INN-Latin]; BRN 1091849; 31868-18-5; CS 386;
  • CAS Registry Number:
  • Density: 1.44 g/cm3
  • Refractive index: 1.675
  • Safety Statements: Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl− and NOx.
  • Molecular Weight: 363.23784
  • InchiKey: ANUCDXCTICZJRH-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-
    7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)
  • Molecular Formula: C18H16Cl2N2O2
  • Molecular Structure:CAS No:31868-18-5 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,<br />3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

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31868-18-5 Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-

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References of 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,
3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
Title: Mexazolam
CAS Registry Number: 31868-18-5
CAS Name: 10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Synonyms: 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyloxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
Manufacturers' Codes: CS-386
Trademarks: Melex (Sankyo); Melium (Han Wha); Sedoxil (Bial)
Molecular Formula: C18H16Cl2N2O2
Molecular Weight: 363.24
Percent Composition: C 59.52%, H 4.44%, Cl 19.52%, N 7.71%, O 8.81%
Literature References: Prepn from 2-amino-2￠,5-dichlorobenzophenone: R. Tachikawa et al., DE 1812252; eidem, US 3772371 (1969, 1973 to Sankyo). Synthesis via Schiff base, physical properties: T. Miyadera et al., J. Med. Chem. 14, 520 (1971). Acid-base equilibrium: M. Ikeda, T. Nagai, Chem. Pharm. Bull. 30, 3810 (1982). Effect on socially induced suppression in monkeys: T. Kamioka et al., Psychopharmacology 52, 17 (1977). Toxicity studies: H. Masuda et al., Sankyo Kenkyusho Nempo 30, 175 (1978), C.A. 90, 180217d. Clinical effects on anxiety and pyschomotor performance in generalised anxiety disorder: L. Ferreira et al., Clin. Drug Invest. 23, 235 (2003).
Properties: Crystals, mp 172-175°. pKa 6.69. LD50 in male, female mice; male, female rats (mg/kg): 4687, 4571, 810, 4500 orally; >6000, >6000, >4000, >4000 i.p. or s.c. (Masuda).
Melting point: mp 172-175°
pKa: pKa 6.69
Toxicity data: LD50 in male, female mice; male, female rats (mg/kg): 4687, 4571, 810, 4500 orally; >6000, >6000, >4000, >4000 i.p. or s.c. (Masuda)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.