Home > Name List By 2 > 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid

CAS No 31842-01-0 , 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid

  • Name: 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid
  • Synonyms: 31842-01-0; Flosin; Indoprofene [INN-French];Isindone; Indoprofenum [INN-Latin]; K 4277; Reumofene; Flosint; Indoprofeno [INN-Spanish];2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid;
  • CAS Registry Number:
  • Flash Point: 263°C
  • Boiling Point: 511.3°Cat760mmHg
  • Density: 1.308g/cm3
  • Refractive index: 1.642
  • Safety Statements: Poison by ingestion. An anti-inflammatory agent and analgesic. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T: Toxic;
  • Flash Point: 263°C
  • EINECS: 250-833-0
  • Molecular Weight: 281.3059
  • InchiKey: RJMIEHBSYVWVIN-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15
    (13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)
  • Risk Statements: 25-40
  • Molecular Formula: C17H15NO3
  • Molecular Structure:CAS No:31842-01-0 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid

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31842-01-0 Indoprofen

  • Indoprofen, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

31842-01-0 Indoprofen

  • Indoprofen, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
Contact Supplier

31842-01-0 INDOPROFEN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]propanoic acid
Title: Indoprofen
CAS Registry Number: 31842-01-0
CAS Name: 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-methylbenzeneacetic acid
Synonyms: p-(1-oxo-2-isoindolinyl)hydratropic acid; 2-[4-(1-carboxyethyl)phenyl]-1-isoindolinone; 1-oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline; 2-[4-(1-oxo-2-isoindolinyl)phenyl]propionic acid; IPP
Manufacturers' Codes: K-4277
Trademarks: Bor-Ind (Borromeo); Flosin (Erba); Flosint (Erba); Isindone (Erba); Praxis (Lisapharma); Reumofene (Von Boch)
Molecular Formula: C17H15NO3
Molecular Weight: 281.31
Percent Composition: C 72.58%, H 5.37%, N 4.98%, O 17.06%
Literature References: Nonsteroidal anti-inflammatory agent. Prepn: BE 753600; R. W. J. Carney, G. de Stevens, US 4316850 (1970, 1982 both to Ciba); P. N. Giraldi et al., DE 2154525 (1972 to Carlo Erba), C.A. 77, 88292v (1972); G. Nannini et al., Arzneim.-Forsch. 23, 1090 (1973). Synthesis and resolution of enantiomers: F. Buzzetti et al., DE 2258088 (1974 to Carlo Erba), C.A. 81, 13382y (1974); T. Kametani et al., J. Heterocycl. Chem. 15, 369 (1978). Abs config: S. De Munari et al., Tetrahedron Lett. 21, 2273 (1980). Pharmacology: A. Buttinoni et al., Arzneim.-Forsch. 23, 1100 (1973). Absorption, excretion and metabolism: G. C. Goldaniga et al., ibid. 24, 1603 (1974); L. F. Chasseaud et al., ibid. 1606. GLC determn of enantiomers in plasma: G. P. Tosolini et al., J. Pharm. Sci. 63, 1072 (1974). Biological activity and toxicity data: A. Buttinoni et al., J. Pharm. Pharmacol. 35, 603 (1983).
Properties: Colorless scales from ethanol, mp 213-214°. LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni).
Melting point: mp 213-214°
Toxicity data: LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni)
 
Derivative Type: (+)-Form
CAS Registry Number: 53086-13-8
Synonyms: Dexindoprofen
Trademarks: Nedius (Erba)
Properties: Colorless scales from isopropanol, mp 205-207°. [a]D20 +48° (c = 0.05 in DMSO). LD50 in rats (mg/kg): 31.98 i.v.; 33.75 orally (Buttinoni).
Melting point: mp 205-207°
Optical Rotation: [a]D20 +48° (c = 0.05 in DMSO)
Toxicity data: LD50 in rats (mg/kg): 31.98 i.v.; 33.75 orally (Buttinoni)
 
Derivative Type: (-)-Form
CAS Registry Number: 53086-14-9
Properties: Colorless scales from isopropanol, mp 205-207°. [a]D20 -48° (c = 0.05 in DMSO). LD50 in rats (mg/kg): 555.39 i.v.; 538.02 orally (Buttinoni).
Melting point: mp 205-207°
Optical Rotation: [a]D20 -48° (c = 0.05 in DMSO)
Toxicity data: LD50 in rats (mg/kg): 555.39 i.v.; 538.02 orally (Buttinoni)
 
Therap-Cat: Analgesic; anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives; Analgesic (Non-Narcotic).
 
 
Status: This monograph has been retired and is no longer subject to revision or update.