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CAS No 31282-04-9 , Hygromycin B

  • Name: Hygromycin B
  • Synonyms: Hygromycin B Streptomyces hygroscopicus; Hygromycin B; hygromycin B aqueous solution;Hygromycin B; Hygromycin B - Solution; Hygromycin B solution Streptomyces hygroscopicus;hygromycin B from streptomyces*hygroscopicus; hygromycin B plant cell culture tested;O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine;
  • CAS Registry Number:
  • Transport: UN 3462
  • Melting Point: 160-180 ºC
  • Density: 1.67 g/cm3
  • Refractive index: 1.672
  • Safety Statements: R26/27/28;R41;R42/43
  • Hazard Symbols: T+: Very toxic;
  • EINECS: 250-545-5
  • Molecular Weight: 527.52
  • InChI: InChI=1/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1
  • Risk Statements: S22;S26;S28;S36/37/39;S45
  • Molecular Formula: C20H37N3O13
  • Molecular Structure:CAS No:31282-04-9 Hygromycin B

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References of Hygromycin B
Title: Hygromycin B
CAS Registry Number: 31282-04-9
CAS Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1?2-3)-O-b-D-talopyranosyl-(1?5)-2-deoxy-N3-methyl-D-streptamine
Trademarks: Hygromix (Elanco)
Molecular Formula: C20H37N3O13
Molecular Weight: 527.52
Percent Composition: C 45.54%, H 7.07%, N 7.97%, O 39.43%
Literature References: Antibiotic substance produced by Streptomyces hygroscopicus (Jensen) Waksman & Henrici, from soil samples from Nebraska and Indiana: Mann, Bromer, J. Am. Chem. Soc. 80, 2714 (1958). Prodn: McGuire, Mann, US 3018220 (1962 to Lilly). Structure: Neuss et al., Helv. Chim. Acta 53, 2314 (1970). Studies on mode of action: A. Gonzalez et al., Biochim. Biophys. Acta 521, 459 (1978).
Properties: Amorphous powder, dec 160-180°. Weakly basic. pKa 7.1, 8.8. [a]D20 +20.2° (c = 1 in water). Freely sol in water, methanol and ethanol. Practically insol in less polar solvents. Absorption spectrum: Mann, Bromer, loc. cit.
pKa: pKa 7.1, 8.8
Optical Rotation: [a]D20 +20.2° (c = 1 in water)
Therap-Cat-Vet: Anthelmintic (swine and chicken).