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CAS No 30578-37-1 , 6-methoxy-1-phenylpyridazin-1-ium-4-amine

  • Name: 6-methoxy-1-phenylpyridazin-1-ium-4-amine
  • Synonyms: Supratonin; Amezinium methylsulfate; Amezinium methyl sulfate; Ameziniummetilsulfat [German];6-methoxy-1-phenylpyridazin-1-ium-4-amine; Regulton;methyl sulfate; amezinium metilsulfate;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.
  • Flash Point: °C
  • EINECS: 250-248-0
  • Molecular Weight: 313.3296
  • InchiKey: ZEASXVYVFFXULL-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-
    5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4)
  • Molecular Formula: C12H15N3O5S
  • Molecular Structure:CAS No:30578-37-1 6-methoxy-1-phenylpyridazin-1-ium-4-amine

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30578-37-1 amezinium methylsulfate

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References of 6-methoxy-1-phenylpyridazin-1-ium-4-amine
Title: Amezinium Methyl Sulfate
CAS Registry Number: 30578-37-1
CAS Name: 4-Amino-6-methoxy-1-phenylpyridazinium methyl sulfate
Manufacturers' Codes: LU-1631
Trademarks: Regulton (Knoll); Risumic (Dainippon); Supratonin (Grñenthal)
Molecular Formula: C12H15N3O5S
Molecular Weight: 313.33
Percent Composition: C 46.00%, H 4.83%, N 13.41%, O 25.53%, S 10.23%
Literature References: Sympathomimetic agent with vascular and cardiac activity. Prepn: F. Richenender, R. Kropp, DE 1912941; eidem, US 3631038 (1970, 1971 both to BASF). Series of articles on synthesis, pharmacology, mechanism of action, metabolism, pharmacokinetics, bioavailability, clinical trials: Arzneim.-Forsch. 31, 1527-1671 (1981). Acute toxicity data: H. J. Teschendorf, ibid. 1580. HPLC determn in human plasma: D. Hotz, E. Brode, J. Chromatogr. 277, 217 (1983). Disposition and identification of major metabolites in rats: K. Nambu et al., Arzneim.-Forsch. 38, 909 (1988).
Properties: Crystals from water, mp 176° (dec). LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf).
Melting point: mp 176° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf)
Therap-Cat: Antihypotensive.
Keywords: Antihypotensive.