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CAS No 28657-80-9 , 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

  • Name: 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
  • Synonyms: Cinoxacine;Cinobac; 28657-80-9; Compound 64716; Clinoxacin; Cinoxacino; Azolinic Acid; Cinoxacinum;1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid; Cinobactin;
  • CAS Registry Number:
  • Flash Point: 266.6°C
  • Boiling Point: 517.2°C at 760 mmHg
  • Density: 1.64g/cm3
  • Refractive index: 1.708
  • Safety Statements: Moderately toxic by ingestion, subcutaneous and intravenous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 266.6°C
  • EINECS: 249-133-8
  • Molecular Weight: 262.2182
  • InchiKey: VDUWPHTZYNWKRN-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12
    (16)17/h3-4H,2,5H2,1H3,(H,16,17)
  • Molecular Formula: C12H10N2O5
  • Molecular Structure:CAS No:28657-80-9 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid

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References of 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
Title: Cinoxacin
CAS Registry Number: 28657-80-9
CAS Name: 1-Ethyl-1,4-dihydro-4-oxo[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
Synonyms: 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid
Manufacturers' Codes: compd 64716
Trademarks: Cinobac (Lilly); Noxigram (Firma); Uronorm (Alfa)
Molecular Formula: C12H10N2O5
Molecular Weight: 262.22
Percent Composition: C 54.96%, H 3.84%, N 10.68%, O 30.51%
Literature References: Quinolone antibacterial; analog of oxolinic acid, q.v. Prepn: W. A. White, DE 2005104; idem, US 3669965 (1970, 1972 both to Lilly). In vitro and in vivo study: W. E. Wick et al., Antimicrob. Agents Chemother. 4, 415 (1973). Pharmacology: J. J. Szwed et al., J. Antimicrob. Chemother. 4, 451 (1978); K. S. Israel et al., J. Clin. Pharmacol. 18, 491 (1978). Metabolism: R. L. Wolen et al. in Stable Isotopes, T. A. Baillie, Ed. (Univ. Park Press, Baltimore, 1978) pp 113-125. Clinical studies: S. Colleen et al., J. Antimicrob. Chemother. 3, 579 (1977); S. N. Rous, J. Urol. 120, 196 (1978). Toxicity: I. Narama et al., Chemotherapy (Tokyo) 28, Suppl. 4, 406 (1980), C.A. 94, 25007 (1981). Pharmacokinetics: M. Ohkawa et al., J. Antimicrob. Chemother. 8, 447 (1981); R. Barbhaiya et al., Antimicrob. Agents Chemother. 21, 472 (1982). Review: J. M. Scavone et al., Pharmacotherapy 2, 266-271 (1982). Review of pharmacology and therapeutic efficacy: T. S. Sisca et al., Drugs 25, 544-569 (1983).
Properties: Light tan crystals, mp 261-262° (dec). Sol in most polar organic solvents. LD50 in rats (mg/kg): 4160 orally; 900 i.v. (Narama).
Melting point: mp 261-262° (dec)
Toxicity data: LD50 in rats (mg/kg): 4160 orally; 900 i.v. (Narama)
 
Derivative Type: Sodium salt
Molecular Formula: C12H9N2NaO5
Molecular Weight: 284.20
Percent Composition: C 50.71%, H 3.19%, N 9.86%, Na 8.09%, O 28.15%
Properties: White crystalline solid. Sol in aqueous solvents.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.