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CAS No 27591-97-5 , 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one

  • Name: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
  • Synonyms: NCGC00095196-01; Tilorone hydrochloride; Tilorona [INN-Spanish];Bis-DEAE-fluorenone;2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one; 27591-69-1; Tiloronum [INN-Latin]; BRN 2011558;
  • CAS Registry Number:
  • Flash Point: 287.8°C
  • Boiling Point: 552.3°Cat760mmHg
  • Density: 1.102g/cm3
  • Refractive index: 1.563
  • Flash Point: 287.8°C
  • Molecular Weight: 410.54906
  • InchiKey: MPMFCABZENCRHV-UHFFFAOYSA-N
  • InChI: InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-
    14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3
  • Molecular Formula: C25H34N2O3
  • Molecular Structure:CAS No:27591-97-5 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one

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References of 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
Title: Tilorone
CAS Registry Number: 27591-97-5
CAS Name: 2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one
Synonyms: bis-DEAE-fluorenone
Molecular Formula: C25H34N2O3
Molecular Weight: 410.55
Percent Composition: C 73.14%, H 8.35%, N 6.82%, O 11.69%
Literature References: The first recognized synthetic, small mol wt compound that is an orally active interferon inducer: Krueger, Mayer, Science 169, 1213 sqq. (1970). Prepn: Fleming et al., DE 1964761 corresp to US 3592819 (1970, 1971 to Richardson Merrell); E. R. Andrews et al., J. Med. Chem. 17, 882 (1974); H. M. Burke, M. M. Joullie, ibid. 21, 1084 (1978). Mechanism of action: De Clercq, Merigan, J. Infect. Dis. 123, 190 (1971). Toxicity studies: Kaufman et al., Proc. Soc. Exp. Biol. Med. 137, 357 (1971). Review: P. Chandra et al., "Tilorone Hydrochloride" in Antibiotics vol. 5(pt. 2), F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 385-413.
 
Derivative Type: Dihydrochloride
CAS Registry Number: 27591-69-1
Molecular Formula: C25H34N2O3.2HCl
Molecular Weight: 483.47
Percent Composition: C 62.11%, H 7.51%, N 5.79%, O 9.93%, Cl 14.67%
Properties: Crystals from butanone-methanol, mp 235-237°. uv max (water): 269 nm (E1%1cm 1600). LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer).
Melting point: mp 235-237°
Absorption maximum: uv max (water): 269 nm (E1%1cm 1600)
Toxicity data: LD50 in mice, rats (single dose): 959, 852 mg/kg orally; 145, 244 mg/kg i.p. (Krueger, Mayer)