Home > Name List By 4 > 4-[(4-butyl-3,5-dioxo-1, 2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid

CAS No 27470-51-5 , 4-[(4-butyl-3,5-dioxo-1,
2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid

  • Name: 4-[(4-butyl-3,5-dioxo-1,
    2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
  • Synonyms: 27470-51-5;Suxibuzona; Flogos; Alfide; Calibene; Solurol; Flamilon;4-[(4-butyl-3,5-dioxo-1,
    2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid; Aflogan; Suxibuzonum;
  • CAS Registry Number:
  • Flash Point: 310.7°C
  • Boiling Point: 590.1°C at 760 mmHg
  • Density: 1.265g/cm3
  • Refractive index: 1.579
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 310.7°C
  • EINECS: 248-477-6
  • Molecular Weight: 438.47304
  • InchiKey: ONWXNHPOAGOMTG-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-
    10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,
    27,28)
  • Risk Statements: S36
  • Molecular Formula: C24H26N2O6
  • Molecular Structure:CAS No:27470-51-5 4-[(4-butyl-3,5-dioxo-1,<br />2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid

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27470-51-5 Suxibuzone

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27470-51-5 Butanedioic acid,1-[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester

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27470-51-5 Suxibuzone

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27470-51-5 SUXIBUZONE

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References of 4-[(4-butyl-3,5-dioxo-1,
2-diphenylpyrazolidin-4-yl)methoxy]-4-oxobutanoic acid
Title: Suxibuzone
CAS Registry Number: 27470-51-5
CAS Name: Butanedioic acid mono[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester
Synonyms: succinic acid monoester with 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione; 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester); 1,2-diphenyl-4-n-butyl-4-hydroxymethyl-3,5-dioxopyrazolidine hemisuccinate; 4-hydroxymethylbutazolidine hemisuccinate
Manufacturers' Codes: AE-17
Trademarks: Calibène (Delalande); Danilon (Esteve); Flogos (Gentili); Solurol (Delalande)
Molecular Formula: C24H26N2O6
Molecular Weight: 438.47
Percent Composition: C 65.74%, H 5.98%, N 6.39%, O 21.89%
Literature References: Prodrug of phenylbutazone, q.v. Prepd (not claimed) and use as anti-inflammatory: A. Esteve, DE 1936747; idem, US 3752894 (1970, 1973 both to Lab. Esteve). Pharmacology: A. Esteve et al., Quim. Ind. (Madrid) 17, 107 (1971). HPLC determn in plasma and urine: T. Marunaka et al., J. Pharm. Sci. 69, 1258 (1980). Metabolism in humans: Y. Yasuda et al., ibid. 71, 565 (1982). Comparative clinical study with phenylbutazone in rheumatoid arthritis: Y. Mizushima et al., Int. J. Tissue React. 5, 35 (1983).
Properties: White, bitter crystalline powder from alcohol, mp 126-127°. Sol in most organic solvents. Insol in water. LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973).
Melting point: mp 126-127°
Toxicity data: LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973)
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Analgesic, antipyretic, anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Pyrazolones.