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CAS No 2622-26-6 , 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile

  • Name: 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
  • Synonyms: Nemactil; Periciazinum; Propericiazine;PERICYAZINE; Aolept;10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile; Periciazina; Piperocyanomazine; Neulactil; Neuleptil;
  • CAS Registry Number:
  • Melting Point: 365.492
  • Flash Point: 312.7°C
  • Boiling Point: 593.4°Cat760mmHg
  • Density: 1.32g/cm3
  • Refractive index: 1.694
  • Safety Statements: Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN−, NOx, and SOx. See also NITRILES.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 312.7°C
  • EINECS: 220-071-3
  • Molecular Weight: 365.49182
  • InchiKey: LUALIOATIOESLM-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)
    11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
  • Risk Statements: 22-36/37/38-20/21/22
  • Molecular Formula: C21H23N3OS
  • Molecular Structure:CAS No:2622-26-6 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile

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References of 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Title: Pericyazine
CAS Registry Number: 2622-26-6
CAS Name: 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile
Synonyms: 2-cyano-10-[3-(4-hydroxypiperidino)propyl]phenothiazine; periciazine; propericiazine
Manufacturers' Codes: RP-8908
Trademarks: Aolept (Bayer); Neulactil (M & B); Neuleptil (Aventis)
Molecular Formula: C21H23N3OS
Molecular Weight: 365.49
Percent Composition: C 69.01%, H 6.34%, N 11.50%, O 4.38%, S 8.77%
Literature References: Psychotherapeutic phenothiazine. Prepn: Robert, Jacques, FR 1212031 (1960 to Rh?ne-Poulenc). Hypotensive action in dogs: K. P. Singh et al., Indian J. Med. Res. 58, 1467 (1970). GLC determn in human urine: A. P. De Leenheer, J. Pharm. Sci. 63, 389 (1974). Clinical studies in psychiatric patients: U. Spiegelberg, G. Kleu, Arzneim.-Forsch. 17, 159 (1967); J. C. Barker, M. Miller, Br. J. Psychiatry 115, 169 (1969). Toxicity and metabolism: L. Julou et al., Proc. Eur. Soc. Study Drug Toxic. 9, 11 (1968). Toxicity data: Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972). Use in spectrophotometry: H. Gowda et al., Anal. Chem. 55, 1816 (1983); A. T. Gowda et al., Anal. Chim. Acta 154, 347 (1983).
Properties: Crystals, mp 116-117°. uv max: 232.5, 271.5 nm (log e 4319, 4503). LD50 orally in rats: 395 mg/kg (Schafer).
Melting point: mp 116-117°
Absorption maximum: uv max: 232.5, 271.5 nm (log e 4319, 4503)
Toxicity data: LD50 orally in rats: 395 mg/kg (Schafer)
Use: Spectrophotometric reagent for palladium and ruthenium.
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.