Home > Name List By 3 > 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide

CAS No 2609-46-3 , 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide

  • Name: 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
  • Synonyms: Guanamprazin; Amipramizide; Amilorida [INN-Spanish]; Amipramizid;Amipramidin;3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; Amiloridum [INN-Latin]; Guanamprazine; Midamor;
  • CAS Registry Number:
  • Density: 2.11g/cm3
  • Refractive index: 1.884
  • EINECS: 220-024-7
  • Molecular Weight: 229.62702
  • InchiKey: XSDQTOBWRPYKKA-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,
    13)(H4,10,11,14,15)
  • Molecular Formula: C6H8ClN7O
  • Molecular Structure:CAS No:2609-46-3 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
Search by region :

Select to

2609-46-3 2-Pyrazinecarboxamide,3,5-diamino-N-(aminoiminomethyl)-6-chloro-

Contact Supplier

2609-46-3 AMILORIDE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
Contact Supplier

2609-46-3 Amiloride

  • China Haihang Industry Co., Ltd. null
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, null,nullChina
Contact Supplier

2609-46-3 Amiloride

Contact Supplier

2609-46-3 Amiloride

  • India JAI RADHE SALES null
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. null,nullIndia
Contact Supplier

2609-46-3 Amiloride

  • India Manus Aktteva null
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, null,nullIndia
Contact Supplier

2609-46-3 Amiloride

  • China Betapharma(Shanghai)Co., Ltd. null
  • Tel: +86-(21)-33538380
  • Fax: +86-(21)-32082820
  • Address: No.17#-6D. 830 Lane, Maotai Road, Shanghai 200336, null,nullChina
Contact Supplier

2609-46-3 Amiloride

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
Contact Supplier

2609-46-3 Amiloride

  • India Exim-Pharm International null
  • Tel: +91-(22)-26191948
  • Fax: +91-(22)-26191948
  • Address: 1, Ashish Mahal, 2nd Floor, Ist Road, Golibar Santacruz (E), Mumbai, Maharashtra 400 055, null,nullIndia
Contact Supplier

2609-46-3 2-Pyrazinecarboxamide,3,5-diamino-N-(aminoiminomethyl)-6-chloro-

Contact Supplier

Select to

References of 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
Title: Amiloride
CAS Registry Number: 2609-46-3
CAS Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
Synonyms: N-amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-amidino-3,5-diamino-6-chloropyrazinamide; 1-(3,5-diamino-6-chloropyrazinecarboxyl)guanidine; 1-(3,5-diamino-6-chloropyrazinoyl)guanidine; guanamprazine; amipramidin; amipramizide
Molecular Formula: C6H8ClN7O
Molecular Weight: 229.63
Percent Composition: C 31.38%, H 3.51%, Cl 15.44%, N 42.70%, O 6.97%
Literature References: Sodium channel blocker. Prepn: E. J. Cragoe, Jr., BE 639386; idem, US 3313813 (1964, 1967 both to Merck & Co.). NMR study on tautomerism and conformation: R. L. Smith et al., J. Am. Chem. Soc. 101, 191 (1979). Pharmacology: Baer et al., J. Pharmacol. Exp. Ther. 157, 472 (1967); Baba et al., Clin. Pharmacol. Ther. 9, 318 (1968); Lant et al., ibid. 10, 50 (1969). Metabolism: Weiss et al., ibid. 401. Clinical evaluation in cystic fibrosis: M. R. Knowles et al., N. Engl. J. Med. 322, 1189 (1990); in combination with uridine 5¢-triphosphate, q.v.: W. D. Bennett et al., Am. J. Respir. Crit. Care Med. 153, 1796 (1996). Reviews: H. L. Macfie et al., Drug Intell. Clin. Pharm. 15, 94-98 (1981); D. E. Hyams, Int. Congr. Symp. Ser. - R. Soc. Med. 44, 65-73 (1981). Comprehensive description of hydrochloride: D. J. Mazzo, Anal. Profiles Drug Subs. 15, 1-34 (1986). Review of mechanism of action: T. R. Kleyman, E. J. Cragoe, Jr., Semin. Nephrol. 8, 242-248 (1988).
Properties: Solid, mp 240.5-241.5°.
Melting point: mp 240.5-241.5°
 
Derivative Type: Hydrochloride dihydrate
CAS Registry Number: 17440-83-4
Manufacturers' Codes: MK-870
Trademarks: Amikal (GEA); Midamor (Merck & Co.); Modamide (Merck & Co.)
Molecular Formula: C6H8ClN7O.HCl.2H2O
Molecular Weight: 302.12
Percent Composition: C 23.85%, H 4.34%, Cl 23.47%, N 32.45%, O 15.89%
Properties: Crystalline solid, dec 285-288°. Anhydr, mp 293.5°. uv max (water): 212, 285, 362 nm (E1%1cm 642, 555, 617). pKa 8.7. Freely sol in DMSO, slightly sol in water, isopropanol, ethanol. Practically insol in acetone, chloroform, diethyl ether, ethyl acetate.
Melting point: mp 293.5°
pKa: pKa 8.7
Absorption maximum: uv max (water): 212, 285, 362 nm (E1%1cm 642, 555, 617)
 
Derivative Type: Hydrochloride dihydrate mixture with hydrochlorothiazide
Synonyms: Co-amilozide
Trademarks: Amil-Co (Baker Norton); Aquaretic (Azupharma); Ecodurex (Ecosol); Grodurex (Grossmann); Hexarese (Durascan); Moduretic (Merck & Co.); Moduretik (Merck & Co.); Normetic (Abbott); Normorix (Nycomed)
 
Therap-Cat: Diuretic.
Keywords: Diuretic.