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CAS No 25614-03-3 , Bromocriptine

  • Name: Bromocriptine
  • Synonyms: Bromocriptine; Bromocryptin; Bromocryptine; Ergoset; Bromoergocryptine; Bromergocryptine; Bromoergocriptine; Bromocriptinum;Bromocriptin; Bagren;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 1.696
  • Safety Statements: Poison by intravenous and possibly other routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the respiratory system, musculoskeletal system, urogenital system, craniofacial area and body wall. Human systemic effects by ingestion including: olfaction changes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes such as Br− and NOx.
  • EINECS: 247-128-5
  • Molecular Weight: 654.5945
  • InchiKey: OZVBMTJYIDMWIL-AYFBDAFISA-N
  • InChI: InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)
    30(41)31(43-32,
    17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)
    15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,
    23-,24+,25+,31-,32+/m1/s1
  • Molecular Formula: C32H40BrN5O5
  • Molecular Structure:CAS No:25614-03-3 Bromocriptine

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25614-03-3 Bromocriptine

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References of Bromocriptine
Title: Bromocriptine
CAS Registry Number: 25614-03-3
CAS Name: (5￠a)-2-Bromo-12￠-hydroxy-2￠-(1-methylethyl)-5￠-(2-methylpropyl)ergotaman-3￠,6￠,18-trione
Synonyms: 2-bromoergocryptine; 2-bromo-a-ergokryptin
Manufacturers' Codes: CB-154
Molecular Formula: C32H40BrN5O5
Molecular Weight: 654.59
Percent Composition: C 58.71%, H 6.16%, Br 12.21%, N 10.70%, O 12.22%
Literature References: Dopamine receptor agonist; derivative of the ergotoxin group of ergot alkaloids. Prepn: E. Flückiger et al., DE 1926045; eidem, US 3752814 (1969, 1973 both to Sandoz). Pharmacology: E. Flückiger, H. R. Wagner, Experientia 24, 1130 (1968); E. Del Pozo et al., Schweiz. Med. Wochenschr. 103, 847 (1973). Relationship of stereochemistry and biological activity: H. P. Weber, Adv. Biochem. Psychopharmacol. 23, 25 (1980); N. Camerman, A. Camerman, Mol. Pharmacol. 19, 517 (1981). Long term clinical trial in Parkinson's disease: T. Nakanishi et al., Eur. Neurol. 32, Suppl. 1, 9 (1992). Clinical effect on body weight and glucose tolerance in obesity: A. H. Cincotta, A. H. Meier, Diabetes Care 19, 667 (1996). Comprehensive description: D. A. Giron-Forest, W. D. Sch?nleber, Anal. Profiles Drug Subs. 8, 47-81 (1979). Review of pharmacology, toxicology and therapeutic uses: D. Parkes, Adv. Drug Res. 12, 247-344 (1977); of therapeutic applications in endocrine and neurological diseases: K. Y. Ho, M. O. Thorner, Drugs 36, 67-82 (1988).
Properties: Crystals from methyl ethyl ketone-isopropyl ether, mp 215-218° (dec). [a]D20 -195° (c = 1 in methylene chloride).
Melting point: mp 215-218° (dec)
Optical Rotation: [a]D20 -195° (c = 1 in methylene chloride)
 
Derivative Type: Methanesulfonate
CAS Registry Number: 22260-51-1
Manufacturers' Codes: CB-154 mesylate
Trademarks: Parlodel (Novartis); Pravidel (Novartis)
Molecular Formula: C32H40BrN5O5.CH3SO3H
Molecular Weight: 750.70
Percent Composition: C 52.80%, H 5.91%, Br 10.64%, N 9.33%, O 17.05%, S 4.27%
Properties: Crystals from methyl ethyl ketone, mp 192-196° (dec). [a]D20 +95° (c = 1 in methanol-methylene chloride). Soly at 25° (mg/ml): methanol 910; ethanol 23.0; water 0.8; chloroform 0.45; benzene <0.1; hexane <0.1. pKa 4.90. LD50 in mice, rats, rabbits (mg/kg): 190, 72, 12.5 i.v. (Parkes).
Melting point: mp 192-196° (dec)
pKa: pKa 4.90
Optical Rotation: [a]D20 +95° (c = 1 in methanol-methylene chloride)
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 190, 72, 12.5 i.v. (Parkes)
 
Therap-Cat: Prolactin inhibitor; antiparkinsonian.
Keywords: Antiparkinsonian; Dopamine Receptor Agonist; Prolactin Inhibitor.