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CAS No 2557-49-5 , Diflorasone Search by region : China

  • Name: Diflorasone
  • Synonyms: (6S,8S,9S,10S,11S,13S,14S,16S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;Diflorasone;-;
  • CAS Registry Number:
  • Flash Point: 298.4 ºC
  • Boiling Point: 569.8 ºC at 760 mmHg
  • Density: 1.36 g/cm3
  • Refractive index: 1.579?
  • Flash Point: 298.4 ºC
  • EINECS: 219-875-7
  • Molecular Weight: 410.46
  • InChI: InChI=1/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
  • Molecular Formula: C22H28F2O5
  • Molecular Structure:CAS No:2557-49-5 Diflorasone

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References of Diflorasone
Title: Diflorasone
CAS Registry Number: 2557-49-5
CAS Name: (6a,11b,16b)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 6a,9a-difluoro-16b-methyl-D1,4-pregnadiene-11b,17a,21-triol-3,20-dione; 6a,9a-difluoro-16b-methylprednisolone
Molecular Formula: C22H28F2O5
Molecular Weight: 410.45
Percent Composition: C 64.38%, H 6.88%, F 9.26%, O 19.49%
Literature References: The 16b-analog of flumethasone, q.v. Prepn of free alcohol and 21-acetate: GB 881334 (1961 to Pfizer), C.A. 56, 15586c (1962); GB 898293; F. H. Lincoln et al., US 3557158 (1962, 1971 both to Upjohn); GB 912015 (1962 to Merck & Co.). Prepn of the 17,21-diacetate: D. E. Ayer et al., DE 2308731; eidem, US 3980778 (1973, 1976 both to Upjohn). Proposed mechanism of action: S. Hammarstrom et al., Science 197, 994 (1977). Pharmacology: S. Wickrema et al., J. Invest. Dermatol. 71, 372 (1978). Clinical study: S. M. Bluefarb et al., J. Int. Med. Res. 4, 454 (1976).
 
Derivative Type: Diacetate
CAS Registry Number: 33564-31-7
Manufacturers' Codes: U-34865
Trademarks: Dermaflor (Brocchieri); Diacort (Pfizer); Florone (Pfizer); Maxiflor (Allergan); Psorcon (Dermik); Soriflor (Nycomed)
Molecular Formula: C26H32F2O7
Molecular Weight: 494.52
Percent Composition: C 63.15%, H 6.52%, F 7.68%, O 22.65%
Properties: Crystals from ethyl acetate-Skellysolve C and acetone-methanol, mp 221-223° (dec). uv max (alc): 238 nm (e 17250). [a]D +61° (chloroform).
Melting point: mp 221-223° (dec)
Optical Rotation: [a]D +61° (chloroform)
Absorption maximum: uv max (alc): 238 nm (e 17250)
 
Therap-Cat: Anti-inflammatory (topical); glucocorticoid.
Keywords: Glucocorticoid.