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CAS No 2470-73-7 , 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]
ethanol

  • Name: 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]
    ethanol
  • Synonyms: BRN 0768050; UCB 3412;Esucos;2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]
    ethanol; (2-Methyl-3-(1-hydroxyethoxyethyl-4-piperazinyl)propyl)-10-phenothiazine; EINECS 219-591-3; 2470-73-7;
  • CAS Registry Number:
  • Flash Point: 310.6°C
  • Boiling Point: 590°Cat760mmHg
  • Density: 1.166g/cm3
  • Refractive index: 1.597
  • Safety Statements: Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of SOx and NOx.
  • Flash Point: 310.6°C
  • EINECS: 219-591-3
  • Molecular Weight: 427.60272
  • InchiKey: MSYUMPGNGDNTIQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H33N3O2S/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-
    27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27/h2-9,20,28H,10-19H2,1H3
  • Molecular Formula: C24H33N3O2S
  • Molecular Structure:CAS No:2470-73-7 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]<br />ethanol

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References of 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]
ethanol
Title: Dixyrazine
CAS Registry Number: 2470-73-7
CAS Name: 2-[2-[4-[2-Methyl-3-(10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethoxy]ethanol
Synonyms: 10-[2-methyl-3-(4-hydroxyethoxyethyl-1-piperazinyl)propyl]phenothiazine; 1-[2-(2-hydroxyethoxy)ethyl]-4-[2-methyl-3-(10-phenothiazinyl)propyl]piperazine
Manufacturers' Codes: UCB-3412
Trademarks: Esucos (UCB); Roscal (Reumert)
Molecular Formula: C24H33N3O2S
Molecular Weight: 427.60
Percent Composition: C 67.41%, H 7.78%, N 9.83%, O 7.48%, S 7.50%
Literature References: Prepn: H. Morren, GB 861420 (1961). Partition properties: B.-A. Persson, Acta Pharm. Suec. 5, 335 (1968). GC-MS determn in blood: G. Brante et al., Eur. J. Clin. Pharmacol. 20, 307 (1981). Clinical pharmacokinetics: H. Liedholm et al., Drug-Nutr. Interact. 3, 87 (1985). Clinical trial in postoperative nausea and vomiting: E. Kokinsky et al., Acta Anaesthesiol. Scand. 43, 191 (1999); A. Johansson et al., ibid. 44, 1093 (2000); as topical anesthetic for cataract surgery: E. Monestam et al., J. Cataract Refract. Surg. 27, 445 (2001). Review of clinical chemistry and early clinical studies: T. Fokstuen, Int. J. Neuropsychiat. 340, 294-299 (1965).
Properties: pKa1: 7.8; pKa2: 3.65.
pKa: pKa1: 7.8; pKa2: 3.65
 
Derivative Type: Dihydrochloride
CAS Registry Number: 60539-20-0
Molecular Formula: C24H33N3O2S.2HCl
Molecular Weight: 500.52
Percent Composition: C 57.59%, H 7.05%, N 8.40%, O 6.39%, S 6.41%, Cl 14.17%
Properties: Crystals from isopropanol, mp 192°.
Melting point: mp 192°
 
Therap-Cat: Antipsychotic; antiemetic; anesthetic (local).
Keywords: Antipsychotic; Phenothiazines; Antiemetic; Anesthetic (Local).