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CAS No 2447-57-6 , 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide

  • Name: 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
  • Synonyms: Fanasil; Sulforthomidine; Sulphormethoxine; Fanzil; Sulfadoxina; Sulfadoxin;Sulphadoxine; 2447-57-6; Sulfadoxinum;4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide;
  • CAS Registry Number:
  • Melting Point: 190-194 ºC
  • Flash Point: 270
  • Boiling Point: 522.8 ºCat 760 mmHg
  • Density: 1.441 g/cm3
  • Refractive index: 1.622
  • Safety Statements: Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. See also .
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 270
  • EINECS: 219-504-9
  • Molecular Weight: 310.32896
  • InchiKey: PJSFRIWCGOHTNF-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,
    18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
  • Risk Statements: 36/37/38
  • Molecular Formula: C12H14N4O4S
  • Molecular Structure:CAS No:2447-57-6 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide

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References of 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
Title: Sulfadoxine
CAS Registry Number: 2447-57-6
CAS Name: 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Synonyms: N￠-(5,6-dimethoxy-4-pyrimidinyl)sulfanilamide; 6-(4-aminobenzenesulfonamido)-4,5-dimethoxypyrimidine; 4-sulfanilamido-5,6-dimethoxypyrimidine; sulforthomidine; sulphormethoxine
Manufacturers' Codes: Ro-4-4393
Trademarks: Fanasil (Roche)
Molecular Formula: C12H14N4O4S
Molecular Weight: 310.33
Percent Composition: C 46.44%, H 4.55%, N 18.05%, O 20.62%, S 10.33%
Literature References: Dihydropteroate synthetase inhibitor. Prepn: BE 618639; H. Bretschneider et al., US 3132139 (1962, 1964 both to Hoffmann-La Roche). Toxicological, chemotherapeutic and pharmacokinetic studies: E. B?hni et al., Chemotherapy 14, 195-226 (1969). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. 17, 571-605 (1988). Enzyme inhibition in vitro: Y. Zhang, S. R. Meshnick, Antimicrob. Agents Chemother. 35, 267 (1991). Determn in plasma using supercritical fluid chromatography: S. I. Bhoir et al., J. Chromatogr. B 757, 39 (2001). Clinical trial of combination with pyrimethamine, q.v., for malaria: C. V. Plowe et al., Br. Med. J. 328, 545 (2004).
Properties: Crystals from 50% aq alc, mp 190-194°. Practically insol in ether. Very slightly sol in water, slightly sol in alcohol, methanol. Sol in dilute mineral acids, solutions of alkali hydroxides and carbonates. LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (B?hni).
Melting point: mp 190-194°
Toxicity data: LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (B?hni)
 
Derivative Type: Mixture with trimethoprim
CAS Registry Number: 39295-60-8
Trademarks: Animar (Pfizer); Bimotrim (Vetpharma); Borgal (Intervet)
 
Therap-Cat: Antibacterial; antimalarial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides; Antimalarial.