Home > Name List By b > Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester

CAS No 23779-99-9 , Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester

  • Name: Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester
  • Synonyms: Idarac;Anthranilicacid, N-[8-(trifluoromethyl)-4-quinolyl]-, 2,3-dihydroxypropyl ester (8CI); R 4138;Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester;Floctafenin;Glycerol, 1-[N-[8-(trifluoromethyl)-4-quinolyl]anthranilate] (8CI); Floctafenine; Diralgan; R 4318; RU 15750; Idalon; Novodolan;
  • CAS Registry Number:
  • Flash Point: 311.9°C
  • Boiling Point: 592.1°C at 760 mmHg
  • Density: 1.437g/cm3
  • Refractive index: 1.63
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. Used as an analgesic.
  • Flash Point: 311.9°C
  • EINECS: 245-881-4
  • Molecular Weight: 406.39
  • InChI: InChI=1/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
  • Molecular Formula: C20H17 F3 N2 O4
  • Molecular Structure:CAS No:23779-99-9 Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester

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References of Benzoic acid,2-[[8-(trifluoromethyl)-4-quinolinyl]amino]-, 2,3-dihydroxypropyl ester
Title: Floctafenine
CAS Registry Number: 23779-99-9
CAS Name: 2-[[8-(Trifluoromethyl)-4-quinolinyl]amino]benzoic acid 2,3-dihydroxypropyl ester
Synonyms: N-[8-(trifluoromethyl)-4-quinolyl]anthranilic acid 2,3-dihydroxypropyl ester; 4-[o-(2￠,3￠-dihydroxypropyloxycarbonyl)phenyl]amino-8-trifluoromethylquinoline; 8-trifluoromethyl-7-deschloroglafenine
Manufacturers' Codes: R-4318; RU-15750
Trademarks: Idalon (HMR); Idarac (HMR); Novodolan (HMR)
Molecular Formula: C20H17F3N2O4
Molecular Weight: 406.36
Percent Composition: C 59.11%, H 4.22%, F 14.03%, N 6.89%, O 15.75%
Literature References: Prepn: A. Allais, J. Meier, DE 1815467; eidem, US 3644368 (1969, 1972, both to Roussel-UCLAF); G. Mouzin et al., Synthesis 1980, 54. Analgesic activity: Allais et al., Chim. Ther. 8, 154 (1973); M. Peterfalvi et al., Arch. Int. Pharmacodyn. Ther. 216, 97 (1975). Clinical investigation: Stenport, Curr. Ther. Res. 18, 303 (1975). Toxicology: R. Glomot et al., Toxicol. Appl. Pharmacol. 36, 173 (1976). Metabolism: R. K. Lynn et al., J. Clin. Pharmacol. 19, 20 (1979).
Properties: Crystals from methanol, mp 179-180°. Sol in alcohol, acetone; very slightly sol in ether, chloroform, methylene chloride. Insol in water. LD50 in male mice, rats (mg/kg): 3400, 960 orally; 180, 160 i.v. (Glomot).
Melting point: mp 179-180°
Toxicity data: LD50 in male mice, rats (mg/kg): 3400, 960 orally; 180, 160 i.v. (Glomot)
Therap-Cat: Analgesic.
Keywords: Analgesic (Non-Narcotic).