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CAS No 216503-57-0 , Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI)

  • Name: Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI)
  • Synonyms: Alemtuzumab;CamPath; Campath 1H; Campath 1H/LDP03;Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI);
  • CAS Registry Number:
  • Molecular Weight: 0
  • InChI: InChI=1S/C38H67NO10/c1-14-28-23(6)30(40)24(7)32-20(3)17-38(11,49-32)34(48-36-31(41)27(39(12)15-2)16-21(4)45-36)25(8)33(26(9)35(42)46-28)47-29-19-37(10,43-13)18-22(5)44-29/h21-31,33-34,36,40-41H,14-19H2,1-13H3/t21-,22+,23+,24-,25+,26-,27+,28-,29+,30+,31-,33+,34-,36+,37+,38-/m1/s1
  • Molecular Formula: C38H67NO10
  • Molecular Structure:CAS No:216503-57-0 Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI)

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References of Immunoglobulin G1,anti-(human CD52 (antigen)) (human-rat monoclonal CAMPATH-1H g1-chain), disulfide withhuman-rat monoclonal CAMPATH-1H light chain, dimer (9CI)
Title: Alemtuzumab
CAS Registry Number: 216503-57-0
CAS Name: Anti-(human CD52 (antigen)) immunoglobulin G1 (human-rat monoclonal CAMPATH-1H g1-chain) disulfide with human-rat monoclonal CAMPATH-1H light chain, dimer
Synonyms: Campath-1H
Manufacturers' Codes: LDP-03
Trademarks: Campath (Schering AG); MabCampath (Schering AG)
Literature References: Humanized monoclonal antibody directed against the pan-lymphocyte antigen, CD52. Induces complement-mediated cytolysis resulting in lymphocyte depletion. Prepn: L. Riechmann et al., Nature 322, 323 (1988); H. Waldmann et al., WO 8907452 (1989 to Medical Research Council); eidem, US 5846534 (1998 to British Technology Group). Structure-activity study: J. Greenwood et al., Eur. J. Immunol. 23, 1098 (1993). Crystal structure of the antibody combining site: G. M. T. Cheetham et al., J. Mol. Biol. 284, 85 (1998). Clinical evaluation in chronic lymphocytic leukemia: A. Osterborg et al., Br. J. Haematol. 93, 151 (1996); in renal transplant patients: R. Calne et al., Transplantation 68, 1613 (1999). Review: F. J. Dumont, Curr. Opin. Invest. Drugs 2, 139-160 (2001).
Therap-Cat: Antineoplastic; immunosuppressant.
Keywords: Antineoplastic; Monoclonal Antibodies; Immunosuppressant.