References of Immunoglobulin G1,anti-(human p185neu receptor) (human-mouse monoclonal rhuMab HER2 g1-chain), disulfide with human-mousemonoclonal rhuMab HER2 light chain, dimer
Title: Trastuzumab
CAS Registry Number: 180288-69-1
CAS Name: Anti-(human p185
neu receptor) immunoglobulin G1 (human-mouse monoclonal rhuMab HER2 g1-chain) disulfide with human-mouse monoclonal rhuMab HER2 light chain, dimer
Synonyms: rhuMab HER2
Trademarks: Herceptin (Genentech)
Literature References: Humanized monoclonal antibody directed against the protein product of the HER2/
neu oncogene which is homologous to the human epidermal growth factor receptor and is overexpressed by certain tumor cells. Constructed by inserting the antigen binding regions of murine monoclonal antibody 4D5 into the framework of a consensus human immunoglobulin G1. Prepn: R. M. Hudziak
et al., WO 8906692;
eidem, US 5677171 (1989, 1997 both to Genentech); P. Carter
et al., Proc. Natl. Acad. Sci. USA 89, 4285 (1992). Analysis by capillary electrophoresis: G. Hunt
et al., J. Chromatogr. A 744, 295 (1996). Clinical evaluation in combination with cisplatin in breast cancer: M. D. Pegram
et al., J. Clin. Oncol. 16, 2659 (1998). Review of clinical efficacy: G. N. Hortobagyi,
Semin. Oncol. 28, Suppl. 18, 43-47 (2001); of clinical safety and tolerability in breast cancer: S. Rueckert
et al., Expert Opin. Biol. Ther. 5, 853-866 (2005).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Monoclonal Antibodies.
