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CAS No 212141-54-3 , N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

  • Name: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • Synonyms: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; Pynasunate; CGP-797870; 212141-54-3;N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK/ZK; CGP 79787;Vatalanib base;
  • CAS Registry Number:
  • Melting Point: 209-212ºC
  • Density: 1.33 g/cm3
  • Refractive index: 1.711
  • Molecular Weight: 346.8129
  • InchiKey: YCOYDOIWSSHVCK-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-
    25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
  • Molecular Formula: C20H15ClN4
  • Molecular Structure:CAS No:212141-54-3 N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

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References of N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
Title: Vatalanib
CAS Registry Number: 212141-54-3
CAS Name: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Synonyms: 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine
Manufacturers' Codes: CGP-79787
Molecular Formula: C20H15ClN4
Molecular Weight: 346.81
Percent Composition: C 69.26%, H 4.36%, Cl 10.22%, N 16.15%
Literature References: Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor; vascular endothelial angiogenesis inhibitor. Prepn: G. Bold et al., WO 9835958; eidem, US 6258812 (1998, 2001 both to Novartis); eidem, J. Med. Chem. 43, 2310 (2000). Enzyme inhibition study and pharmacology: J. M. Wood et al., Cancer Res. 60, 2178 (2000). Antiangiogenic activity: J. Drevs et al., ibid. 62, 4015 (2002). Clinical pharmacokinetics: B. Morgan et al., J. Clin. Oncol. 21, 3955 (2003). Review of mechanism of action: P. Furet, P. W. Manley ACS Symp. Ser. 796, 282-298 (2001); and therapeutic potential: A. L. Thomas et al., Semin. Oncol. 30, Suppl. 6, 32-38 (2003).
Properties: Crystals from water + diethyl ether, mp 209-212°.
Melting point: mp 209-212°
 
Derivative Type: Succinate
CAS Registry Number: 212142-18-2
Manufacturers' Codes: CGP-79787D; PTK-787; ZK-222584
Molecular Formula: C20H15ClN4.C4H6O4
Molecular Weight: 464.90
Percent Composition: C 62.00%, H 4.55%, Cl 7.63%, N 12.05%, O 13.77%
Properties: Crystals from ethanol, mp 195°.
Melting point: mp 195°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Tyrosine Kinase Inhibitors.