Home > Name List By n > N-[2-[[4-[2-(6,7-dimethoxy-3, 4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4, 5-dimethoxyphenyl]quinoline-3-carboxam...

CAS No 206873-63-4 , N-[2-[[4-[2-(6,7-dimethoxy-3,
4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,
5-dimethoxyphenyl]quinoline-3-carboxamide

  • Name: N-[2-[[4-[2-(6,7-dimethoxy-3,
    4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,
    5-dimethoxyphenyl]quinoline-3-carboxamide
  • Synonyms: CHEBI:359664;206873-63-4; XR 9576; Tariquidar (USAN/INN); XR9576;N-[2-[[4-[2-(6,7-dimethoxy-3,
    4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,
    5-dimethoxyphenyl]quinoline-3-carboxamide; CHEMBL348475; XR-9576; AC1L3WN5; UNII-J58862DTVD;
  • CAS Registry Number:
  • Flash Point: 386.8°C
  • Boiling Point: 716°Cat760mmHg
  • Density: 1.276g/cm3
  • Refractive index: 1.662
  • Flash Point: 386.8°C
  • Molecular Weight: 646.73152
  • InchiKey: LGGHDPFKSSRQNS-UHFFFAOYSA-N
  • InChI: InChI=1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-
    13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)
    27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,
    44)(H,41,43)
  • Molecular Formula: C38H38N4O6
  • Molecular Structure:CAS No:206873-63-4 N-[2-[[4-[2-(6,7-dimethoxy-3,<br />4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,<br />5-dimethoxyphenyl]quinoline-3-carboxamide

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206873-63-4 3-Quinolinecarboxamide,N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-

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206873-63-4 3-Quinolinecarboxamide,N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-

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References of N-[2-[[4-[2-(6,7-dimethoxy-3,
4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,
5-dimethoxyphenyl]quinoline-3-carboxamide
Title: Tariquidar
CAS Registry Number: 206873-63-4
CAS Name: N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide
Manufacturers' Codes: XR-9576
Molecular Formula: C38H38N4O6
Molecular Weight: 646.73
Percent Composition: C 70.57%, H 5.92%, N 8.66%, O 14.84%
Literature References: Multidrug resistance modulator; selective inhibitor of P-glycoprotein (P-gp), q.v. Prepn: H. Ryder et al., WO 9817648; eidem, US 6218393 (1998, 2001 both to Xenova); M. Roe et al., Bioorg. Med. Chem. Lett. 9, 595 (1999). Molecular interaction with P-gp: C. Martin et al., Br. J. Pharmacol. 128, 403 (1999). Effect on multidrug resistant cell lines: P. Mistry et al., Cancer Res. 61, 749 (2001). Clinical pharmacology: A. Stewart et al., Clin. Cancer Res. 6, 4186 (2000). Effect on accumulation of 99mTc-sestamibi, q.v., in patients with metastatic cancers: M. Agrawal et al., Clin. Cancer Res. 9, 650 (2003).
Therap-Cat: Antineoplastic adjunct (chemosensitizer).
Keywords: Antineoplastic Adjunct; Chemosensitizer.