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CAS No 205110-48-1 , Cethromycin

  • Name: Cethromycin
  • Synonyms: CETHROMYCIN;Cethromycin;11-Amino-11-deoxy-3-oxo-5-o-desosaminyl-6-o-[1'-(3'-quinolyl-2'-propenyl)] erythronolide A 11,12-cyclic carbamate;CETHROMYCIN(ABT-773);
  • CAS Registry Number:
  • Flash Point: 514.5°C
  • Boiling Point: 927.1°Cat760mmHg
  • Density: 1.22g/cm3
  • Refractive index: 1.578
  • Flash Point: 514.5°C
  • Molecular Weight: 765.932
  • InChI: InChI=1/C42H59N3O10/c1-11-32-42(8)36(44-40(50)55-42)25(4)33(46)23(2)21-41(7,51-18-14-15-28-20-29-16-12-13-17-30(29)43-22-28)37(26(5)34(47)27(6)38(49)53-32)54-39-35(48)31(45(9)10)19-24(3)52-39/h12-17,20,22-27,31-32,35-37,39,48H,11,18-19,21H2,1-10H3,(H,44,50)/b15-14+/t23-,24-,25-,26+,27-,31+,32+,35-,36-,37-,39+,41-,42-/m1/s1
  • Molecular Formula: C42H59N3O10
  • Molecular Structure:CAS No:205110-48-1 Cethromycin

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205110-48-1 ABT-773

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205110-48-1 Cethromycin

  • Cethromycin, Min 99%
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References of Cethromycin
Title: Cethromycin
CAS Registry Number: 205110-48-1
CAS Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-3a,7,9,11,13,15-hexamethyl-11-[[3-(3-quinolinyl)-2-propenyl]oxy]-10-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylohexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
Manufacturers' Codes: A-195773; ABT-773
Molecular Formula: C42H59N3O10
Molecular Weight: 765.93
Percent Composition: C 65.86%, H 7.76%, N 5.49%, O 20.89%
Literature References: Semisynthetic macrolide antibiotic of the ketolide class; structurally similar to telithromycin, q.v. Prepn: Y. S. Or et al., WO 9809978; eidem, US 5866549 (1998, 1999 both to Abbott); eidem, J. Med. Chem. 43, 1045 (2000). Improved prepn: D. J. Plata et al., Tetrahedron 60, 10171 (2004). Comparative in vitro antibacterial spectrum: A. M. Nilius et al., Antimicrob. Agents Chemother. 45, 2163 (2001). Mechanism of action study: W. S. Champney, J. Pelt, Curr. Microbiol. 45, 155 (2002). HPLC-MS determn in biological samples: Q. Ren et al., J. Chromatogr. Sci. 41, 494 (2003). Clinical pharmacokinetics: M. W. Pletz et al., Antimicrob. Agents Chemother. 47, 1129 (2003). Reviews of development and therapeutic potential: L. E. Lawrence, Curr. Opin. Invest. Drugs 2, 766-772 (2001); T. J. Dougherty, J. F. Barrett, Expert Opin. Invest. Drugs 10, 343-351 (2001).
Properties: White crystalline solid, mp 211-213°.
Melting point: mp 211-213°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.