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CAS No 2043-38-1 , 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ

  • Name: 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ
  • Synonyms: Saltucin;6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ Butizidum [INN-Latin];Butizide;6,2,
    4-benzothiadiazine-7-sulfonamide; isobutylhydrochlorothiazide; Butizida [INN-Spanish]; Eunephran; 2043-38-1; thiabutazide;
  • CAS Registry Number:
  • Flash Point: 294.1°C
  • Boiling Point: 562.7°Cat760mmHg
  • Density: 1.433g/cm3
  • Refractive index: 1.572
  • Flash Point: 294.1°C
  • EINECS: 218-048-8
  • Molecular Weight: 353.84544
  • InchiKey: HGBFRHCDYZJRAO-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H16ClN3O4S2/c1-6(2)3-11-14-8-4-7(12)9(20(13,
    16)17)5-10(8)21(18,19)15-11/h4-6,11,14-15H,3H2,1-2H3,(H2,13,16,17)
  • Molecular Formula: C11H16ClN3O4S2
  • Molecular Structure:CAS No:2043-38-1 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ

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References of 6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-1λ
Title: Buthiazide
CAS Registry Number: 2043-38-1
CAS Name: 6-Chloro-3,4-dihydro-3-(2-methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Synonyms: 6-chloro-3,4-dihydro-3-isobutyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; thiabutazide; butizide; isobutylhydrochlorothiazide
Manufacturers' Codes: Su-6187; S-3500
Trademarks: Eunephran (Servier); Saltucin (Boehringer, Mann.)
Molecular Formula: C11H16ClN3O4S2
Molecular Weight: 353.85
Percent Composition: C 37.34%, H 4.56%, Cl 10.02%, N 11.88%, O 18.09%, S 18.12%
Literature References: Prepd from 5-chloro-2,4-disulfamoylaniline and isovaleraldehyde: Werner et al., J. Am. Chem. Soc. 82, 1161 (1960); GB 861367; GB 885078; G. de Stevens, L. H. Werner, US 3163645 (1961, 1961, 1964 all to Ciba); Topliss et al., J. Org. Chem. 26, 3842 (1961).
Properties: Crystals, mp 241-245° (Werner, 1960); from methanol + chloroform, mp 228° (Topliss). An ingredient of Modenol.
Melting point: mp 241-245° (Werner, 1960); mp 228° (Topliss)
Therap-Cat: Diuretic, antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.