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CAS No 20168-99-4 , 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-

  • Name: 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
  • Synonyms: 1-Cinnamoyl-5-methoxy-2-methylindole-3-acetic acid;1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)- (9CI); Cindomet; Indolacin;1-Cinnamoyl-2-methyl-5-methoxyindolyl-3-acetic acid;Cinmethacin;1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-; Indole-3-aceticacid, 1-cinnamoyl-5-methoxy-2-methyl- (8CI); Cinmetacin;
  • CAS Registry Number:
  • Flash Point: 248.9°C
  • Boiling Point: 488°Cat760mmHg
  • Density: 1.19g/cm3
  • Refractive index: 1.593
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 248.9°C
  • EINECS: 243-555-6
  • Molecular Weight: 349.39
  • InChI: InChI=1/C21H19NO4/c1-14-17(13-21(24)25)18-12-16(26-2)9-10-19(18)22(14)20(23)11-8-15-6-4-3-5-7-15/h3-12H,13H2,1-2H3,(H,24,25)/b11-8+
  • Molecular Formula: C21H19 N O4
  • Molecular Structure:CAS No:20168-99-4 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-

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References of 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
Title: Cinmetacin
CAS Registry Number: 20168-99-4
CAS Name: 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid
Synonyms: 1-cinnamoyl-5-methoxy-2-methylindole-3-acetic acid; 1-cinnamoyl-2-methyl-5-methoxy-3-indolylacetic acid
Trademarks: Cindomet (Chiesi); Indolacin (Sumitomo)
Molecular Formula: C21H19NO4
Molecular Weight: 349.38
Percent Composition: C 72.19%, H 5.48%, N 4.01%, O 18.32%
Literature References: Prepn: H. Yamamoto, M. Nakao, ZA 6702683; eidem, US 3576800 (1968, 1971 both to Sumitomo); eidem, J. Med. Chem. 12, 176 (1969). Pharmacology: T. Komatsu et al., Arzneim.-Forsch. 23, 1690 (1973).
Properties: Yellow crystals from acetone-water, mp 170-172°; also reported as mp 164-165°. LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu).
Melting point: mp 170-172°; mp 164-165°
Toxicity data: LD50 in mice, rats (mg/kg): 360, 590 i.p.; 750, 1020 orally (Komatsu)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.