Home > Name List By 4 > 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2, 4-triazolidin-1-yl]benzoic acid

CAS No 201530-41-8 , 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,
4-triazolidin-1-yl]benzoic acid

  • Name: 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,
    4-triazolidin-1-yl]benzoic acid
  • Synonyms: Exjade; DSSTox_CID_28522; Deferasiroxum [INN-Latin]; ICL 670A; Deferasiroxum; 201530-41-8; ICL 670; ICL670;4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,
    4-triazolidin-1-yl]benzoic acid;
  • CAS Registry Number:
  • Melting Point: 260-2620C
  • Flash Point: 347.5°C
  • Boiling Point: 651°Cat760mmHg
  • Density: 1.472g/cm3
  • Refractive index: 1.699
  • Flash Point: 347.5°C
  • Molecular Weight: 373.3615
  • InchiKey: FMSOAWSKCWYLBB-VBGLAJCLSA-N
  • InChI: InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24
    (23-19)14-11-9-13(10-12-14)21(27)28/h1-12,22-23H,(H,27,28)/b19-15-,
    20-16+
  • Molecular Formula: C21H15N3O4
  • Molecular Structure:CAS No:201530-41-8 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,<br />4-triazolidin-1-yl]benzoic acid
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201530-41-8 DEFERASIROX

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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201530-41-8 Benzoic acid,4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-

  • China Hangzhou Sage Chemical Co., Ltd. [, Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, ,ZhejiangChina
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201530-41-8 Benzoic acid,4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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201530-41-8 Deferasirox

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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201530-41-8 deferasirox

  • deferasirox
  • China sales@credimate.com [Manufacturer]
  • Tel: +86 21 51872179
  • Fax: +86 21 51872179
  • Address: Room 2110, Tower 1, Changan Mansion, No. 1001 Changan Road200070 ShanghaiCHINA Shanghai,China
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201530-41-8 Deferasirox

  • Deferasirox, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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201530-41-8 Deferasirox

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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201530-41-8 Deferasirox

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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201530-41-8 Benzoic acid,4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-

  • China Maple Chemical Co.,ltd. [Manufacturer]
  • Tel: 86-574- 87512300
  • Fax: 86-574-82095182
  • Address: No.347,Sanbei Road,Sanbei Town,Cixi ,Zhejiang,China Ningbo,ZhejiangChina
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201530-41-8 DEFERASIROX-D4

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. ,India
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References of 4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,
4-triazolidin-1-yl]benzoic acid
Title: Deferasirox
CAS Registry Number: 201530-41-8
CAS Name: 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
Manufacturers' Codes: ICL-670; ICL-670A; CGP-72670
Trademarks: Exjade (Novartis)
Molecular Formula: C21H15N3O4
Molecular Weight: 373.36
Percent Composition: C 67.56%, H 4.05%, N 11.25%, O 17.14%
Literature References: Orally active tridentate iron chelator. Prepn: R. Lattmann, P. Acklin, WO 9749395; eidem, US 6465504 (1997, 2002 both to Novartis); U. Heinz et al., Angew. Chem. Int. Ed. 38, 2568 (1999). HPLC determn in plasma: M. C. Rouan et al., J. Chromatogr. B 755, 203 (2001). Iron complex formation study: S. Steinhauser et al., Eur. J. Inorg. Chem. 2004, 4177. Pharmacology: C. Hershko et al., Blood 97, 1115 (2001). Clinical pharmacokinetics: R. Galanello et al., J. Clin. Pharmacol. 43, 565 (2003). Clinical trial in thalassemia: E. Nisbet-Brown et al., Lancet 361, 1597 (2003). Review of structure activity: H. Nick et al., Curr. Med. Chem. 10, 1065-1076 (2003); of preclinical and clinical experience: M. D. Cappellini, Best Prac. Res. Clin. Haematol. 18, 289-298 (2005).
Properties: Crystals from ethanol, mp 264-265°. Soly in water at 25° (mg/ml): 0.4 (pH 7.40). pKa1 4.57, pKa2 8.71, pKa3 10.56 (Nick). Also reported in H2O/DMSO (CDMSO = 0.20) as pKa1 4.61, pKa2 10.12, pKa3 12.08 (Steinhauser). Partition coefficient (octanol/water): 6.3 (pH 7.40). uv max (H2O/DMSO, pH < 2): 284 nm (e 1.5 ′ 104).
Melting point: mp 264-265°
pKa: pKa1 4.57, pKa2 8.71, pKa3 10.56 (Nick); Also reported in H2O/DMSO (CDMSO = 0.20) as pKa1 4.61, pKa2 10.12, pKa3 12.08 (Steinhauser)
Log P: Partition coefficient (octanol/water): 6.3 (pH 7.40)
Absorption maximum: uv max (H2O/DMSO, pH < 2): 284 nm (e 1.5 ′ 104)
Therap-Cat: Chelating agent (iron).
Keywords: Chelating Agent.